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ProteomicsRegional vulnerability of brain white matter in VWM
Vanishing white matter (VWM) is a leukodystrophy that primarily manifests in young children. In this disease, the brain white matter is differentially affected in a predictable pattern with telencephalic brain areas being more severely affected, while others remain allegedly completely spared. Using...
ORGANISM(S): Homo sapiens (Human) 
2023-06-28 | PXD040861 | Pride
Astrocytopathy Leukodystrophy Vanishing white matter Regional vulnerability 
TranscriptomicsDifferential gene expression in mouse retina related to regional differences in vulnerability to hyperoxia
Purpose: In the C57BL/6J mouse retina, hyperoxia-induced degeneration of photoreceptors shows strong regional variation, beginning at a locus ~0.5mm inferior to the optic disc. To identify gene expression differences that might underlie this variability in vulnerability, we have used microarray tech...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-21246 | biostudies-arrayexpress
TranscriptomicsGenes and Pathways Underlying Regional and Cell Type Changes in Alzheimer's Disease
Along with the two hallmark pathologies—intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques—transcriptional studies suggest that Alzheimer's disease (AD) results from dysfunction of many cellular pathways including synaptic transmission, cytoskeletal dynamics, and apoptosi...
ORGANISM(S): Homo sapiens 
2013-06-07 | E-GEOD-29378 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in mouse retina related to regional differences in vulnerability to hyperoxia
Purpose: In the C57BL/6J mouse retina, hyperoxia-induced degeneration of photoreceptors shows strong regional variation, beginning at a locus ~0.5mm inferior to the optic disc. To identify gene expression differences that might underlie this variability in vulnerability, we have used microarray tech...
ORGANISM(S): Mus musculus 
2010-04-08 | GSE21246 | GEO
TranscriptomicsHippocampal subfield transcriptomic profiles: Regional vulnerability to age and cognitive impairment
The current study employed next-generation RNA sequencing to examine gene expression related to brain aging and cognitive decline. Young and aged rats were trained on a spatial episodic memory task. Hippocampal regions CA1, CA3 and the dentate gyrus (DG) were isolated. Poly-A mRNA was examined using...
ORGANISM(S): Rattus norvegicus 
2017-12-08 | GSE97608 | GEO
UnknownAn AHP-based regional COVID-19 vulnerability model and its application in China.
Not available
S-EPMC8317685 | biostudies-literature
UnknownTranscriptomic signatures of brain regional vulnerability to Parkinson's disease.
Not available
S-EPMC7058608 | biostudies-literature
UnknownNeuronal activity regulates the regional vulnerability to amyloid-β deposition.
Not available
S-EPMC3102784 | biostudies-literature
UnknownMolecular properties underlying regional vulnerability to Alzheimer's disease pathology.
Not available
S-EPMC6113636 | biostudies-literature
UnknownDegree and direction of overlap between social vulnerability and community resilience measurements.
Not available
S-EPMC9584515 | biostudies-literature
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