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TranscriptomicsAbnormal Developmental Control of Replication Timing Domains in Pediatric Acute Lymphoblastic Leukemia
Abnormal replication timing has been observed in cancer but no study has comprehensively evaluated this misregulation. We generated genome-wide replication timing profiles for pediatric leukemias from 17 patients and 3 cell lines, as well as normal B and T cells. Non-leukemic EBV-transformed lymphob...
ORGANISM(S): Homo sapiens 
2012-05-16 | E-GEOD-37987 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation profiling of CD4+ T cells and CD19+ B cells in autoimmune-disease associated HLA class II genotype carriers (HLA-DR2-DQ6, -DR3-DQ2 and -DR4-DQ8 homozygotes) using Illumina Infinium HumanMethylation EPIC beadchip
The Human leukocyte antigen (HLA) -region, especially HLA class I and II genes, plays a major role in the predisposition to autoimmune disorders. Particularly three HLA haplotypes, DRB1*03-DQA1*05-DQB1*02 (DR3-DQ2), DRB1*04:01-DQA1*03-DQB1*03:02 (DR4-DQ8) and DRB1*15-DQA1*01-DQB1*06:02 (DR2-DQ6), ha...
ORGANISM(S): Homo sapiens 
2024-06-20 | E-MTAB-13654 | biostudies-arrayexpress
UnknownAutoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.
Not available
S-EPMC4205657 | biostudies-literature
UnknownDiabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register.
Not available
S-EPMC2890771 | biostudies-literature
UnknownLong-term outcome after ischemic stroke in relation to comorbidity - An observational study from the Swedish Stroke Register (Riksstroke).
Not available
S-EPMC7092731 | biostudies-literature
UnknownEfficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in patients with haematological and solid malignancies: protocol for a systematic review and meta-analysis.
Not available
S-EPMC5988064 | biostudies-literature
UnknownReversal Treatment in Oral Anticoagulant-Related Intracerebral Hemorrhage-An Observational Study Based on the Swedish Stroke Register.
Not available
S-EPMC7438936 | biostudies-literature
UnknownGenetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults.
Not available
S-EPMC7918850 | biostudies-literature
GenomicsA microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
PRJNA1336759 | ENA
TranscriptomicsRegulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes
In spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the insulin B chain peptide 9-23 (B:9-23) can bind to the MHC class II molecule (IAg7) in register 3 (R3), creating a bimolecular IAg7/InsulinB:9-23 register 3 conformational epitope (InsB:R3). Previously, we showed that the InsB:R3...
ORGANISM(S): Mus musculus 
2023-07-24 | GSE238146 | GEO
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