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MetabolomicsUntargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

BACKGROUND: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the potential for resistance to this d...

2019-09-26 | MTBLS1167 | MetaboLights
UnknownEarly over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity.
Not available
S-EPMC2763872 | biostudies-literature
UnknownGenomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites.
Not available
S-EPMC6375703 | biostudies-literature
TranscriptomicsOver expression of mRNA for multiple genes including insulin in the PLN of NOD is associated with Islet Autoimmunity
The aim of this study is to identify genes implicated in the early steps of the autoimmune process, prior to inflammation in type 1 diabetes. Early Insulin AutoAntibodies (E-IAA) have been used as subphenotypic marker to select individual animals as type 1 diabetes prone and to compare gene expressi...
ORGANISM(S): Mus musculus 
2009-10-02 | E-GEOD-15582 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse with ablation of connexin 30 in the stria vascularis
Effect of the ablation of connexin 30 in the stria vascularis
ORGANISM(S): Mus musculus 
2007-04-16 | E-MEXP-558 | biostudies-arrayexpress
TranscriptomicsGene profiling of quiescent and activated skeletal muscle satellite cells by an in vivo approach
The satellite cell of skeletal muscle provides a paradigm for quiescent and activated tissue stem cell states. We have carried out transcriptome analyses by comparing satellite cells from adult skeletal muscles, where they are mainly quiescent, with cells from growing muscles, regenerating (mdx) mus...
ORGANISM(S): Mus musculus 
2010-01-04 | E-GEOD-15155 | biostudies-arrayexpress
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
UnknownEpithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve.
Not available
S-EPMC3639975 | biostudies-literature
TranscriptomicsGene Expression data from Mouse Balb/c Bone marrow derived macrophages infected by the promastigote form of Leishmania major parasite (P) or Killed parasite (Kp) during a time course of infection [Balb/c]
We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages (BMDM) at different times after infection with promastigotes of the protozoan parasite Leishmania major. GeneChip Mouse Gene 1.0 ST arrays were used to analyse global changes in gene transcripts to generate a pool of...
ORGANISM(S): Mus musculus 
2012-11-19 | E-GEOD-31995 | biostudies-arrayexpress
MetabolomicsNitisinone’s mosquitocidal properties hold promise for malaria control

Nitisinone’s mosquitocidal properties hold promise for malaria control

2025-06-16 | MTBLS11617 | MetaboLights
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