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ProteomicsAnalysis of myosin light chain migration pattern in 2D gels of human left ventricular proteins
The myosin light chain protein family consists of two classes, the regulatory myosin light chains (RLC) and the essential myosin light chains (ELC). Functionally, the MLC proteins are directly involved in sarcomeric activity and force transmission contributing to cardiac contractility. Besides regul...
ORGANISM(S): Homo sapiens (Human) 
2022-07-24 | PXD033908 | Pride
Cardiomyocytes Essential myosin light chains (elc) Phosphorylation Regulatory myosin light chains (rlc) 
TranscriptomicsMYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis
Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26721 | biostudies-arrayexpress
UnknownSingle-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin II function.
Not available
S-EPMC7242715 | biostudies-literature
UnknownInsights into myosin regulatory and essential light chains: a focus on their roles in cardiac and skeletal muscle function, development and disease.
Not available
S-EPMC6879809 | biostudies-literature
UnknownPiperine, an alkaloid inhibiting the super-relaxed state of myosin, binds to the myosin regulatory light chain.
Not available
S-EPMC6699511 | biostudies-literature
UnknownModification of interface between regulatory and essential light chains hampers phosphorylation-dependent activation of smooth muscle myosin.
Not available
S-EPMC3381165 | biostudies-literature
UnknownDistinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry.
Not available
S-EPMC5526110 | biostudies-literature
UnknownPhosphorylation Mimetic of Myosin Regulatory Light Chain Mitigates Cardiomyopathy-Induced Myofilament Impairment in Mouse Models of RCM and DCM.
Not available
S-EPMC10381296 | biostudies-literature
ProteomicsIn-depth Characterization of S-Glutathionylation of Ventricular Myosin Light Chain 1 Across Species by Top-Down Proteomics
S-glutathionylation (SSG) is increasingly recognized as a critical signaling mechanism in the heart, yet SSG modifications in cardiac sarcomeric proteins remain understudied. Here we identified SSG of the ventricular isoform of myosin light chain 1 (MLC-1v) in human, swine, and mouse cardiac tissues...
ORGANISM(S): Sus Scrofa (ncbitaxon:9823) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-12-09 | MSV000096622 | MassIVE
UnknownMolecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations.
Not available
S-EPMC4764388 | biostudies-literature
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