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MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
MetabolomicsActivation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure

Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy metabolism remain ill-defined. Here we identi...

2026-01-28 | MTBLS13783 | MetaboLights
MetabolomicsTargeted metabolomics of MuRF1 Knockdown cardiomyocytes compared to their wildtype controls (part II)
Not available
ORGANISM(S): Mus musculus 
ST000430 | MetabolomicsWorkbench
MetabolomicsTargeted metabolomics of MuRF1 overexpressing cardiomyocytes compared to their wildtype controls (part I)
Not available
ORGANISM(S): Mus musculus 
ST000429 | MetabolomicsWorkbench
MetabolomicsExercise-generated β-aminoisobutyric acid (BAIBA) reduces cardiomyocytes metabolic stress and apoptosis caused by mitochondrial dysfunction through the miR-208b/AMPK pathway

OBJECTIVE: To explore the cardioprotective effects of exercise-derived β-aminoisobutyric (BAIBA) on cardiomyocyte apoptosis and energy metabolism in a rat model of heart failure (HF).

METHODS: In male Sprague-Dawley rats (8-week-old), myocardial infarction ...

2022-03-08 | MTBLS3927 | MetaboLights
ProteomicsThe role of Rpl3l in translation in cardiomyocytes
Ribosome immunoprecipitates of cardiomyocytes isolated from Rpl3l-/- and Rpl3l+/+ mouse hearts were analysed using mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-08 | PXD026985 | Pride
Rpl3 Cardiomyocytes Rpl3l 
MetabolomicsTFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes (part-I)
Not available
ORGANISM(S): Homo sapiens 
ST001246 | MetabolomicsWorkbench
ProteomicsBioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium
In the current study we examined several proteomic- and RNA-Seq-based datasets of cardiac-enriched, cell-surface and membrane-associated proteins in human fetal and mouse neonatal ventricular cardiomyocytes. By integrating available microarray and tissue expression profiles along with MGI phenotypic...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-11-17 | PXD017732 | Pride
Bioinformatics Therapeutics Cardiomyocytes Membrane proteins Heart disease 
ProteomicsSecretome analysis of cardiomyocytes identifies PCSK6 as a novel player in cardiac remodeling after myocardial infarction
Acute occlusion of a coronary artery results in swift tissue necrosis. Bordering areas of the infarcted myocardium may also experience impaired blood supply and reduced oxygen delivery leading to altered metabolic and mechanical processes. While transcriptional changes in hypoxic cardiomyocytes are ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-03-05 | PXD016178 | Pride
Cardiomyocytes Myocardial infarction Remodeling Secretome 
ModelsMcDougal2017 - Metabolism in ischemic cardiomyocytes
Heart disease remains the leading cause of death globally. Although reperfusion following myocardial ischemia can prevent death by restoring nutrient flow, ischemia/reperfusion injury can cause significant heart damage. The mechanisms that drive ischemia/reperfusion injury are not well understood; c...
2024-09-02 | BIOMD0000000961 | BioModels
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