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ProteomicsThe role of Rpl3l in translation in cardiomyocytes
Ribosome immunoprecipitates of cardiomyocytes isolated from Rpl3l-/- and Rpl3l+/+ mouse hearts were analysed using mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-08 | PXD026985 | Pride
Rpl3 Cardiomyocytes Rpl3l 
ProteomicsAC16 (RPL3+) and shRPL3/RPL3L+ (RPL3L-WT) expressing AC16 cells.
To measure absolute abundance of paralogs, AC16 (RPL3+) and shRPL3/RPL3L+ (RPL3L-WT) cells were treated with 400ng/ml doxycycline for 8 days. Cells were pelleted and submitted for label free mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2025-11-15 | PXD066930 | Pride
Ribosome Cardiomyopathy Ac16 Ventricle 
ProteomicsRPL3L Mutant Heart Cells LFQ MS.
Mutations in the tissue-specific ribosomal protein RPL3L lead to infant dilated cardiomyopathy. The current project aims to understand the mechanistic details of disease progression using in vivo biopsies from transplanted heart of patient with RPL3L mutations as well as engineered AC16 cell lines t...
ORGANISM(S): Homo sapiens (Human) 
2025-11-15 | PXD066450 | Pride
Ribosome Cardiomyopathy Ac16 Ventricle 
GenomicsMammalian heart RPL3L
RPL3L-containing ribosomes modulate mitochondrial activity in the mammalian heart.
PRJEB49255 | ENA
GenomicsRPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function
RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function
PRJNA838484 | ENA
GenomicsNano-TRAP Input and IP sequencing of WT and Rpl3l-/- mouse hearts
Nano-TRAP Input and IP sequencing of WT and Rpl3l-/- mouse hearts
PRJNA784937 | ENA
GenomicsRibo-Seq and RNA-seq sequencing of WT and Rpl3l-/- mouse hearts
Ribo-Seq and RNA-seq sequencing of WT and Rpl3l-/- mouse hearts
PRJNA784790 | ENA
GenomicsDefining the effects of Rpl3L-deficiency on transcriptional profiles of mouse hearts
Defining the effects of Rpl3L-deficiency on transcriptional profiles of mouse hearts
PRJNA892477 | ENA
TranscriptomicsRPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function
Although several ribosomal protein (RP) paralogs are expressed in a tissue-specific manner, how these proteins affect translation and why they are required only in certain tissues have remained unclear. Here we show that RPL3L, a paralog of RPL3 specifically expressed in heart and skeletal muscle, i...
ORGANISM(S): Mus musculus 
2023-03-15 | GSE203072 | GEO
TranscriptomicsDefining the effects of Rpl3L-deficiency on transcriptional profiles of mouse hearts
The ribosomal protein L3-like (RPL3L) is a striated muscle-specific ribosomal protein, and mutations in human RPL3L are linked with childhood cardiomyopathy and age-related atrial fibrillation. However, the function served by this protein, a paralogue of the ubiquitously expressed RPL3 protein, rema...
ORGANISM(S): Mus musculus 
2023-02-10 | GSE216168 | GEO
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