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MetabolomicsMulti-omics analyses reveal regulatory networks underpinning metabolite biosynthesis in Nicotiana tabacum

Tobacco is a significant industrial crop, serving as a model for plant science and a promising specie for the production of proteins and small molecules. However, system biology studies of tobacco under natural field cultivation conditions remain scarce. Here, we construct a genome-scale metaboli...

2025-09-30 | MTBLS13081 | MetaboLights
MetabolomicsMulti-omics analyses reveal regulatory networks underpinning metabolite biosynthesis in Nicotiana tabacum

Tobacco is a significant industrial crop, serving as a model for plant science and a promising specie for the production of proteins and small molecules. However, system biology studies of tobacco under natural field cultivation conditions remain scarce. Here, we construct a genome-scale metaboli...

2025-09-29 | MTBLS13071 | MetaboLights
MetabolomicsMulti-omics analyses reveal regulatory networks underpinning metabolite biosynthesis in Nicotiana tabacum

Tobacco is a significant industrial crop, serving as a model for plant science and a promising specie for the production of proteins and small molecules. However, system biology studies of tobacco under natural field cultivation conditions remain scarce. Here, we construct a genome-scale metabol...

2025-09-29 | MTBLS13072 | MetaboLights
MetabolomicsMulti-omics analyses reveal regulatory networks underpinning metabolite biosynthesis in Nicotiana tabacum

Tobacco is a significant industrial crop, serving as a model for plant science and a promising specie for the production of proteins and small molecules. However, system biology studies of tobacco under natural field cultivation conditions remain scarce. Here, we construct a genome-scale metaboli...

2025-09-28 | MTBLS13060 | MetaboLights
MetabolomicsDecoding the Regulatory Networks of Proteus mirabilis Under Succinic Acid Stress: A Multi-Omics Approach

Proteus mirabilis, a key catheter-associated urinary tract infection pathogen that forms antibiotic-resistant crystalline biofilms, was shown via multi-omics analyses to be multimodally inhibited by succinic acid. At 15 mM, succinic acid reduced the bacterium’s growth by 70% and biofilm formation...

2025-09-08 | MTBLS12952 | MetaboLights
MetabolomicsMetabolite Correlation Networks Reveal Complex Phenotypes of Adaptation-Driving Mutations

Living organisms are organized into hierarchical levels of increasing complexity. As mutational effects propagate through these levels, multiple phenotypes are produced. However, identifying which phenotypes influence fitness and drive selection remains a key challenge in understanding genotype-p...

2026-08-10 | MTBLS14569 | MetaboLights
MetabolomicsDiscovery of novel metabolic pathways and regulatory mechanisms of ammonia-oxidizing bacteria in organic materials stabilization

Background Ammonia-oxidizing bacteria (AOB) play a crucial role in the microbiome of the global nitrogen cycle. Yet, their regulatory functions in the metabolic pathways involved in organic material stabilization (OMS) are not fully understood. We employed...

2025-10-23 | MTBLS13207 | MetaboLights
MetabolomicsCombined analysis of transcriptome and metabolome reveals the accumulation of related metabolites and gene regulation networks during faba bean seed development

Background: Faba bean seeds are nutrient-dense, serving as a vital plant-based protein source for food and vegetables. However, the metabolic accumulation and transcriptional regulatory networks during seed development remain poorly understood.

Results: Metabolomic analysis of two developme...

2025-09-02 | MTBLS12471 | MetaboLights
MetabolomicsDefective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity in Arabidopsis

Cytokinin (CK) in plants regulates both developmental processes and adaptation to environmental stress. Arabidopsis histidine phosphotransfer ahp2,3,5 and type-B response regulator arr1,10,12 triple mutants are almost completely defective in CK signaling, and the ahp2,3,5

2021-11-25 | MTBLS2532 | MetaboLights
MetabolomicsRegulatory actors and alternative routes for Arabidopsis seed germination are revealed using a pathway‐based analysis of transcriptomic datasets
Regulation of seed germination by dormancy relies on a complex network of transcriptional and post‐transcriptional modifications during seed imbibition that controls seed adaptive responses to environmental cues. High‐throughput technologies have brought significant progress in the understanding of ...
2019-05-21 | MTBLS662 | MetaboLights
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