Sort   by:  
 Page size 
no omics definedRNAi knock down of GW182 in Drososphila cells compared to cells with knock down of AGO1, a key effector of miRNA-mediated gene silencing
RNA silencing pathways are conserved gene regulation mechanisms that lead to degradation, translational repression or transcriptional silencing of target-transcripts selected based on complementarity with small RNA molecules. Using firefly luciferase reporters, we previously were able show that the ...
ORGANISM(S): Drosophila melanogaster 
2006-10-31 | E-MEXP-487 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of known nonsense-mediated mRNA decay (NMD) factors in Drosophila cells
All eukaryotes studied to date have the capacity to detect and degrade mRNAs harboring premature translation termination codons (PTCs) in a process called nonsense-mediated mRNA decay (NMD) (reviewed in Wagner E & Lykke-Andersen J, 2002). This surveillance system allows the cell to prevent the expre...
ORGANISM(S): Drosophila melanogaster 
2005-11-01 | E-MEXP-202 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of CAF1-CCR4-NOT1 deadenylase complex or AGO1 in D. melanogaster S2 cells
miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. AGO1 is a key protein required for miRNA-mediated gene silencing. In animal cells, mRNA degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, fo...
ORGANISM(S): Drosophila melanogaster 
2008-12-03 | E-MEXP-1713 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of mRNA decapping co-activators in Drosophila S2 cells
We analyzed mRNA expression profiles in Drosophila melanogaster S2 cells that had been depleted of proteins known as mRNA decapping co-activators. mRNA decapping is catalyzed by DCP2, and DCP2 activity is stimulated by decapping co-activators. This group of proteins includes DCP1, Hedls (also known ...
ORGANISM(S): Drosophila melanogaster 
2007-09-03 | E-MEXP-1012 | biostudies-arrayexpress
TranscriptomicsRNAi knock down in Drosophila of THO2 and HPR1 proteins from S2 cells
THO2 and HPR1 proteins were co-depleted from Drosophila S2 cells and their role in mRNA export analysed by comparing total RNA and cytoplasmic RNA
ORGANISM(S): Drosophila melanogaster 
2005-01-01 | E-MEXP-88 | biostudies-arrayexpress
UnknownDeoxyguanosine is a TLR7 agonist.
Not available
S-EPMC6972671 | biostudies-literature
UnknownDeadenylation is a widespread effect of miRNA regulation.
Not available
S-EPMC2612776 | biostudies-literature
UnknownZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.
Not available
S-EPMC10823230 | biostudies-literature
UnknownLow expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.
Not available
S-EPMC9585911 | biostudies-literature
UnknownIn vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis.
Not available
S-EPMC12914052 | biostudies-literature
Sort   by:  
 Page size