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GenomicsDnmt2-dependent methylomes lack biologically relevant DNA methylation patterns
Several organisms belonging to diverse animal groups have retained Dnmt2 as their only bona fide DNA methyltransferase gene. However, recent studies have shown that Dnmt2 functions as a tRNA methyltransferase, which prompted us to analyze the methylomes of Dnmt2-only organisms at single-base resolut...
ORGANISM(S): Mus musculus 
2013-05-06 | E-GEOD-42170 | biostudies-arrayexpress
GenomicsGenome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation
Fertilization triggers a global erasure of 5-methylcytosine from paternal DNA as part of extensive epigenetic reprogramming during the transition from gametic specialization to totipotency. This active removal has been shown to involve oxidation by TET3, but the targeting of this pathway and the wid...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-63417 | biostudies-arrayexpress
UnknownDNMT3A binds ubiquitinated histones to regulate bivalent genes.
Not available
S-EPMC7615034 | biostudies-literature
GenomicsDnmt2-dependent methylomes lack biologically relevant DNA methylation patterns [Schistosoma mansoni]
Dnmt2 is a widely conserved protein, which is closely related to eukaryotic DNA methyltransferases. However, Dnmt2 shows a robust tRNA methyltransferase activity and only limited activity towards DNA. Interestingly, a recent study has provided evidence for a biologically important function of Dnmt2-...
ORGANISM(S): Schistosoma mansoni 
2013-05-06 | E-GEOD-39997 | biostudies-arrayexpress
GenomicsGenome-wide erasure of DNA methylation in mouse primordial germ cells is affected by Aid deficiency
Epigenetic reprogramming including demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, and is important for the erasure of imprints and epimutations, and the return to pluripotency. The extent of this reprogramming and its molecular mechanisms are poorly under...
ORGANISM(S): Mus musculus 
2010-01-26 | E-GEOD-19960 | biostudies-arrayexpress
UnknownTandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region.
Not available
S-EPMC480907 | biostudies-literature
UnknownPooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells.
Not available
S-EPMC8055612 | biostudies-literature
UnknownDeepCpG: accurate prediction of single-cell DNA methylation states using deep learning.
Not available
S-EPMC5387360 | biostudies-literature
UnknownActive demethylation in mouse zygotes involves cytosine deamination and base excision repair.
Not available
S-EPMC4037648 | biostudies-literature
UnknownAmniogenesis occurs in two independent waves in primates.
Not available
S-EPMC9627701 | biostudies-literature
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