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ProteomicsGene-environment interaction elicits dystonia-like features and impaired translational regulation in a DYT-TOR1A mouse model
DYT-TOR1A dystonia is a movement disorder characterized by involuntary muscle contractions. Despite being the most common monogenetic form of dystonia, its pathophysiolofy remains unclear. With a reduced penetrance of about 30%, there is a suggestion that extragenetic factors are needed to develeop ...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-05 | PXD047531 | Pride
Second-hit hypothesis Multi-omic Dyt-tor1a 
ProteomicsPeripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice
DYT-THAP1 dystonia is a monogenetic form of dystonia, a movement disorder characterized by involuntary muscle contractions. The disease is caused by mutations in the THAP1 gene, although the exact mechanisms through which these mutations contribute to dystonia's pathophysiology remain elusive. The i...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-03 | PXD055364 | Pride
Striatum Cerebellum Mouse Cortex Dyt-thap1 
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