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MetabolomicsToxoplasma gondii infection induces metabolic alterations in the mouse cerebellum
Toxoplasma gondii is a protozoan parasite with a remarkable neurotropic affinity. We recently showed that T. gondii infection can alter the global metabolism of the cerebral cortex of the mice. However, the impact of this infection on the metabolism of the cerebellum remained unclear. In this study,...
2020-04-27 | MTBLS1537 | MetaboLights
ProteomicsCircadian analysis of the mouse cerebellum
The cerebellum contains a circadian clock, generating internal temporal signals. The daily oscillations of cerebellar proteins were investigated here in mice using large-scale two-dimensional differences in gel electrophoresis (2D-DIGE). Analysis of 2D-DIGE gels highlighted the rhythmic variation in...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-23 | PXD013039 | Pride
Lc-msms Circadian rhythm Mouse Cerebellum 
ProteomicsMouse cerebellum LC-MSMS: effect of calorie restriction
The cerebellum harbors a circadian clock that can be shifted by scheduled mealtime and participates in behavioral anticipation of food access. To determine which cerebellar proteins are modified by time-of-day and/or feeding time, we determined day-night variations of proteome in the cerebellum of m...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-06 | PXD021056 | Pride
Lc-msms Circadian rhythm Mouse Cerebellum 
TranscriptomicsCerebellar gene expression data from Mecp2-null and MECP2-transgenic mice
We compared gene expression changes in the cerebellum of mice lacking MeCP2 (Mecp2-null) and mice overexpressing MeCP2 (MECP2-transgenic). A group of postnatal neurodevelopmental disorders collectively referred to as MeCP2 disorders are caused by aberrations in the gene encoding methyl-CpG-binding ...
ORGANISM(S): Mus musculus 
2010-04-10 | E-GEOD-15574 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human paediatric medulloblastoma samples and normal cerebellum to investigate the occurance of alternative splicing
Alternative pre-mRNA splicing critically contributes to the generation of protein variety in a tissue- and development-specific manner. Alterations in the normal pathways of alternative splicing (AS) have been associated with the growth and maintenance of several tumour types, and have been indicate...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-MTAB-292 | biostudies-arrayexpress
ProteomicsAnnexin A2 causes motor incoordination via muscle-cerebellum axis in sarcopenia
Annexin A2 causes motor incoordination via muscle-cerebellum axis in sarcopenia
ORGANISM(S): Mus Musculus 
PXD068704 |
ProteomicsAP-2 alpha interaction partners in WT cerebellum
Identification of interaction partners of the alpha adaptin 2 in the cerebellum of 8 weeks old WT mice
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD050090 | Pride
Cerebellum Ap-2 
ProteomicsCaspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology
Contactin-associated protein-like 2 (Caspr2) is a neurexin-like protein that has been associated with numerous neurological conditions. However, the mechanisms underlying Caspr2 function in the central nervous system remain incompletely understood. Here, we report on a functional role for Caspr2 in ...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-13 | PXD018972 | Pride
5-trisphosphate receptor type 1  cerebellum  purkinje cell 4 Caspr2  itpr  inositol 1 
TranscriptomicsMouse cerebellum
Serial analysis of gene expression (SAGE) was used to identify and quantify all expressed cerebellar genes in the adult (P92; GSM17430) and aged (P810; GSM17226) C57BL/6J mouse cerebellum. A "closest-neighbor" algorithm was used to differentiate low abundance tags from possible sequencing ...
ORGANISM(S): Mus musculus 
2004-10-25 | E-GEOD-1090 | biostudies-arrayexpress
ProteomicsPROTEOMIC SIGNATURE OF THE CEREBELLUM IN SCHIZOPHRENIA
Malfunction of multiple regions in distributed brain circuits has been suggested to underlie the diversity of symptoms and cognitive impairments in schizophrenia. The cerebellum, as part of this circuit, may contribute to these symptoms for this reason we undertook a proteomic profile of this region...
ORGANISM(S): Homo sapiens (Human) 
2020-06-22 | PXD008216 | Pride
Schizophrenia Proteomic Cerebellum 
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