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GenomicsGeneration of a new mouse model of glaucoma characterized by reduced expression of the AP-2 and AP-2
This study reports on the generation of a transgenic mouse which is characterized by early-onset angle-closure glaucoma. The phenotype is due to the transgene insertion site which is proximal to the genes encoding AP-2 and AP-2, two proteins present in the retina and corneal epithelium. This leads t...
ORGANISM(S): Mus musculus 
2017-03-10 | E-MTAB-5502 | biostudies-arrayexpress
ProteomicsProteomic analysis of WT and AP-2 KO NPCs at DIV3
Full proteome analysis of WT and AP-2 KO NPCs at DIV3 to detect dysregulated proteins.
ORGANISM(S): Mus musculus (Mouse) 
2023-12-11 | PXD047200 | Pride
Centrosome Ap-2 Microtubules Neuronal progenitors 
ProteomicsWhole proteome from cerebellum of 1 and 2 months old AP-2 cKO and control mice
Identification of whole proteome changes in the cerebellum of AP-2 cko and control mice at 1 and 2 months of age.
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD050031 | Pride
Cerebellum Purkinje cells Ap-2 
ProteomicsPurkinje cell proteome of the cerebellum of AP-2 cKo
Identification of whole proteome changes in Purkinje cells of the cerebellum of AP-2 cKo and control mice at 2 months of age after APEX AAV injection
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD058847 | Pride
Apex Cerebellum Purkinje cells Ap-2 
GenomicsQuantitative analysis of AP-1 dependent gene expression in negative control and AP-1 knockdown myometrium primary cells derived from 2 patient tissue samples.
Quantitative analysis of AP-1 dependent gene expression in negative control and AP-1 knockdown myometrium primary cells derived from 2 patient tissue samples.
PRJNA526892 | ENA
TranscriptomicsActivator protein-2γ is a critical determinant of estrogen receptor interactome formation and gene transcription in breast cancer [expression]
Estrogen receptor α (ERα) is key player in the progression of breast cancer. ERα binds to DNA and mediates long-range chromatin interactions throughout the genome, but the underlying mechanism in this process is unclear. Here, we show that AP-2 motifs are highly enriched in the ERα binding sites...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-26740 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pancreatic cancer cell line BxPC-3 induced by PAR-2 AP
Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor activated by trypsin and coagulant factors, plays broad spectrum of physiological and pathological roles especially in cancer development. In this study, we used PAR-2 activating peptide to mimic the action of trypsin to trigger PAR...
ORGANISM(S): Homo sapiens 
2013-04-30 | E-GEOD-44827 | biostudies-arrayexpress
UnknownTransient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding.
Not available
S-EPMC4921775 | biostudies-literature
GenomicsActivator protein-2M-NM-3 is a critical determinant of estrogen receptor interactome formation and gene transcription in breast cancer [ChIP-Seq]
Estrogen receptor M-NM-1 (ERM-NM-1) is key player in the progression of breast cancer. ERM-NM-1 binds to DNA and mediates long-range chromatin interactions throughout the genome, but the underlying mechanism in this process is unclear. Here, we show that AP-2 motifs are highly enriched in the ERM-NM...
ORGANISM(S): Homo sapiens 
2011-06-03 | E-GEOD-23852 | biostudies-arrayexpress
GenomicsGenetic Framework for GATA Factor Function in Vascular Biology
Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Whereas the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. As many q...
ORGANISM(S): Homo sapiens 
2011-08-11 | E-GEOD-29531 | biostudies-arrayexpress
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