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ProteomicsEvolutionary proteomics uncovers ciliary signaling components
Cilia are organelles specialized for movement and signaling. To infer when during animal evolution signaling pathways became associated with cilia, we characterized the proteomes of cilia from three organisms: sea urchins, sea anemones and choanoflagellates. From these ciliomes, we identified 437 hi...
ORGANISM(S): Nematostella vectensis 
2019-12-16 | PXD006632 | Pride
Cilia Sea anemone Nematostella vectensis Evolution Strongylocentrotus purpuratus Salpingoeca rosetta Sea urchin Signaling Choanoflagellate 
GenomicsPolycomb-like 3 is a PRC2 component that supports embryonic stem cell self-renewal
Polycomb repressive complex 2 (PRC2) trimethylates lysine 27 of histone H3 (H3K27me3), which regulates gene expression and controls diverse biological transitions in development, embryonic stem cell (ESC) differentiation, and cancer. Here we show that Polycomb-like 3 (Pcl3) is a component of PRC2 t...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-28325 | biostudies-arrayexpress
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