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TranscriptomicsRoquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
The degradation of TNFM-NM-1 mRNA is critical for restricting TNFM-NM-1 synthesis and involves a constitutive decay element (CDE) in the 3M-bM-^@M-^Y untranslated region of the mRNA. We demonstrate that the active CDE is a stem-loop RNA motif that is recognized by the RNA-binding protein Roquin. Dee...
ORGANISM(S): Mus musculus 
2013-05-15 | E-GEOD-44775 | biostudies-arrayexpress
TranscriptomicsTranslational regulation of specific mRNAs controls feedback inhibition and survival during macrophage activation [array]
When macrophages encounter pathogens, they transiently induce an orchestrated cascade of pro- and anti-inflammatory genes. We systematically analyzed the contribution of translational regulation to the early phase of macrophage activation. While the expression of most cytokines is regulated by chang...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-52449 | biostudies-arrayexpress
TranscriptomicsHigh temporal resolution of mRNA expression patterns during the early macrophage response to LPS [RNA_Seq]
When macrophages encounter pathogens, they transiently induce an orchestrated cascade of pro- and anti-inflammatory genes. To obtain a precise picture of transcriptome-wide mRNA expression patterns, we performed RNA-Seq of total RNA at a high temporal resolution during the first two hours of macroph...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-52320 | biostudies-arrayexpress
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