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TranscriptomicsTranscription profiling of human bronchoalveolar lavage samples collected from lung transplant recipients with rejection states determined at the time of sample collection
Bronchoalveolar lavage samples collected from lung transplant recipients. Numeric portion of sample name is an arbitrary patient ID and AxBx number indicates the perivascular (A) and bronchiolar (B) scores from biopsies collected on the same day as the BAL fluid was collected. Several patients hav...
ORGANISM(S): Homo sapiens 
2007-08-29 | E-GEOD-2018 | biostudies-arrayexpress
TranscriptomicsMolecular heterogeneity in acute renal allograft rejection
The data set contains 67 array (lymphochip cDNA array), published in N Engl J Med 2003 Jul 10;349(2):125-38. PMID: 12853585. TITLE: Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. BACKGROUND: The causes and clinical course of acute rejection vary, a...
ORGANISM(S): Homo sapiens 
2003-07-01 | E-GEOD-343 | biostudies-arrayexpress
TranscriptomicsAssessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes
Molecular phenotyping of biopsies affords opportunities for increased precision and improved disease classification to address the limitations of conventional histologic diagnostic systems. We applied archetypal analysis, an unsupervised method similar to cluster analysis, to microarray data from 12...
ORGANISM(S): Homo sapiens 
2017-07-10 | E-GEOD-98320 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human renal allograft biopsies reveal conserved rejection signatures and molecular pathways I
Specific early diagnosis of renal allograft rejection is gaining importance in the current trend to minimize and individualize immunosuppression. Gene expression analyses could contribute significantly by defining “molecular Banff” signatures. Several previous studies have applied transcriptomic...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-9489 | biostudies-arrayexpress
TranscriptomicsHeart Transplant Rejection Profiling in Peripheral Blood
PBMC samples from heart transplant patients were profiled. Sample classification was based on endomyocardial biopsy at the time of sample collection. Keywords = Transplant Keywords = Transplantation Keywords = Heart Transplant Keywords = Graft Rejection Keywords = Rejection Keywords = PBMC Keywords ...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2445 | biostudies-arrayexpress
TranscriptomicsKidney transplantation
In this study, we examined transcriptional profiles from 3 different microarray platforms, across 103 peripheral blood samples with and without acute rejection, to find a critical gene-set for the diagnosis of acute renal rejection that matched biopsy diagnosis, irrespective of patient demographics,...
ORGANISM(S): Homo sapiens 
2012-12-26 | E-GEOD-14067 | biostudies-arrayexpress
TranscriptomicsImpact of Animal Strain on Gene Expression in a Rat Model of Acute Cardiac Rejection
The expression levels of many genes show wide natural variation among strains or populations. This study investigated the potential for animal strain-related genotypic differences to confound gene expression profiles in acute cellular rejection (ACR). Additional analysis allowed for selection of 49 ...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-6342 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human endomyocardial biopsies before, during and after cardiac allograft rejection
Cardiac allograft rejection remains a significant clinical problem in the early phase after heart transplantation and requires frequent surveillance with endomyocardial biopsy. Endomyocardial tissue samples were obtained in connection with clinical biopsies from twenty consecutive heart transplant ...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-4315 | biostudies-arrayexpress
TranscriptomicsMyocardial Gene Expression Profiling to Predict and Identify Cardiac Allograft Acute Cellular Rejection
Aims. Serial invasive endomyocardial biopsies (EMB) remain the gold standard for acute cellular rejection (ACR) diagnosis. However histological grading has several limitations. We aimed to explore the value of myocardial Gene Expression Profiling (GEP) for diagnosing and identifying predictive bioma...
ORGANISM(S): Homo sapiens 
2017-03-07 | E-MTAB-5136 | biostudies-arrayexpress
TranscriptomicsKidney Transplant Rejection and Tissue Injury by Gene Profiling of Biopsies and Peripheral Blood Lymphocytes
We used DNA microarrays (HG-U95Av2 GeneChips) to determine gene expression profiles for kidney biopsies and peripheral blood lymphocytes (PBLs) in transplant patients. Sample classes include kidney biopsies and PBLs from patients with 1) healthy normal donor kidneys, 2) well-functioning transplants ...
ORGANISM(S): Homo sapiens 
2004-07-14 | E-GEOD-1563 | biostudies-arrayexpress
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