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MetabolomicsAutomated Label-free Quantification of Metabolites from Liquid Chromatography–Mass Spectrometry Data (Plasma)

Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard technology in metabolomics. In particular, label-free quantification based on LC-MS is easily amenable to large-scale studies and thus well suited to clinical metabolomics. Large-scale studies, however, require autom...

2015-12-16 | MTBLS234 | MetaboLights
MetabolomicsAutomated Label-free Quantification of Metabolites from Liquid Chromatography–Mass Spectrometry Data (Simulated)

Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard technology in metabolomics. In particular, label-free quantification based on LC-MS is easily amenable to large-scale studies and thus well suited to clinical metabolomics. Large-scale studies, however, require autom...

2015-12-16 | MTBLS235 | MetaboLights
MetabolomicsComprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection
Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS data. Although a number of software packages have been developed to facilitate untargeted data proc...
2019-11-19 | MTBLS733 | MetaboLights
MetabolomicsComprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection (AB SCIEX TripleTOF 6600 assay)

Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS data. Although a number of software packages have been developed to facilitate untargeted data p...

2019-11-19 | MTBLS736 | MetaboLights
TranscriptomicsRelative quantification of miRNAs across multiple experiments
MicroRNAs (miRNAs) have been shown to play an important role in many different cellular, developmental, and physiological processes. Accordingly, numerous methods have been established to identify and quantify miRNAs. The shortness of miRNA sequence results in a high dynamic range of melting tempera...
ORGANISM(S): synthetic construct 
2010-06-20 | E-GEOD-15833 | biostudies-arrayexpress
GenomicsRelative quantification of miRNAs across multiple experiments
Relative quantification of miRNAs across multiple experiments
PRJNA116761 | ENA
TranscriptomicsAbsolute quantification of miRNAs
MicroRNAs (miRNAs) have been shown to play an important role in many different cellular, developmental, and physiological processes. Accordingly, numerous methods have been established to identify and quantify miRNAs. The shortness of miRNA sequence results in a high dynamic range of melting tempera...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-15835 | biostudies-arrayexpress
ProteomicsA metabolic labeling strategy for relative protein quantification in Clostridioides difficile
Clostridioides difficile (formerly Clostridium difficile) is a Gram-positive, spore-forming pathogen which cases drug-induced Clostridioides difficile-associated diseases in hospitals worldwide. A detailed analysis of the proteome may provide new targets for drug development or therapy strategies to...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2018-10-25 | PXD010279 | Pride
Proteomics Relative protein quantification Mass spectrometry Metabolic labeling Clostridioides difficile 
TranscriptomicsAbsolute quantification of CD34(+)/CD133(-) hematopoietic stem cells
MicroRNAs (miRNAs) have been shown to play an important role in many different cellular, developmental, and physiological processes. Accordingly, numerous methods have been established to identify and quantify miRNAs. The shortness of miRNA sequence results in a high dynamic range of melting tempera...
ORGANISM(S): synthetic construct 
2009-10-26 | E-GEOD-15831 | biostudies-arrayexpress
ProteomicsSpecific mixing facilitates the comparative quantification of phosphorylation sites with significant dysregulations
It is still a big challenge to accurately quantify the proteins or proteins PTM sites with extreme relative abundances in comparative protein samples, such as the significantly dysregulated ones. Herein, a novel quantification strategy, Mixing at Specific Ratio (MaSR) before isotope labeling, had be...
ORGANISM(S): Candida albicans (Yeast) Homo sapiens (Human) Escherichia coli 
2016-12-06 | PXD005181 | Pride
Lc-msms Mixing at specific ratio Comparative phosphoproteome quantification Stable isotope labeling Extreme relative abundance 
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