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ProteomicsE-selectin Affinity Glycoproteomics Reveals Neuroendocrine Proteins and the Secretin Receptor as a Poor Prognosis Signature in Colorectal Cancer
Colorectal cancer (CRC) cells express glycoproteins with sialylated Lewis antigens (sLe), crucial for metastasis via E-selectin binding. However, these glycoepitopes lack cancer specificity, and E-selectin-targeted glycoproteins are unknown. Here we established a framework for identifying metastasi...
ORGANISM(S): Homo sapiens (Human) 
2024-11-11 | PXD054727 | Pride
Cancer glycoproteome Colorectal cancer E-selectin Secretin receptor Metastasis 
ProteomicsGlycomics and Glycoproteomics Reveal Distinct Oligomannose Carriers Across Bladder Cancer Stages
Aberrant glycosylation is a hallmark of cancer, offering opportunities to enhance clinical decision-making and enable precise targeting of cancer cells. Nevertheless, alterations in the bladder urothelial carcinoma (BLCA) N-glycome remain poorly characterized. Here, we used in situ N-deglycosylation...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD063671 | Pride
Bladder cancer  n-glycomics  n-glycoproteins 
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