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ProteomicsPalmitoylation couples insulin hypersecretion with β-cell failure in diabetes
Hyperinsulinemia often precedes type 2 diabetes but its role in disease progression is unknown. Palmitoylation, a protein modification implicated in regulated exocytosis, is reversed by acyl-protein thioesterase 1 (APT1). We found altered APT1 biology in pancreatic islets from humans with type 2 dia...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-05 | PXD038554 | Pride
Proteomics Palmitoylation Pancreatic islet Insulin Diabetes 
UnknownABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.
Not available
S-EPMC4657583 | biostudies-literature
UnknownABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9.
Not available
S-EPMC6773855 | biostudies-literature
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