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The goal of this investigation was to identify putative targets of the TELOMERASE ACTIVATOR 1 transcription factor. Experiment Overall Design: Total RNA was isolated from leaves of 3 week old plants. We used three biological replicates of wild type (Columbia) and the tac1-1D activation tagged line ...
ORGANISM(S): Arabidopsis thaliana 
Simple and efficient delivery of CRISPR genome editing systems in primary cells remains a major challenge. Here, we describe an engineered Peptide-Assisted Genome Editing (PAGE) CRISPR-Cas system for rapid and robust editing of primary cells. PAGE couples a cell-penetrating Cas protein with a cell-p...
ORGANISM(S): Homo sapiens 
2023-03-20 | GSE223805 | GEO
Background: Examining transcriptional regulation by existing antidepressants in key neural circuits implicated in depression, and understanding the relationship to transcriptional mechanisms of susceptibility and natural resilience, may help in the search for new therapeutics. Further, given the het...
ORGANISM(S): Mus musculus 
Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I interferon (IFN) signaling rapidly shifts the balance of these programs by decreasing synthesis and increasing import of cholesterol and long chain f...
ORGANISM(S): Homo sapiens 
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