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TranscriptomicsThe BEN domain is a novel sequence-specific DNA binding domain conserved in neural transcriptional repressors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2013-04-04 | E-GEOD-44178 | biostudies-arrayexpress
ProteomicsGu-Ben-Fang-Xiao decoction ameliorates airway remodeling by regulating the PI3K/AKT signaling pathway mediated by RTN4 in a chronic remission asthma murine model
Airway remodeling is a main pathological feature of asthma. The current therapy for asthma is mainly targeted for reducing inflammation, not particularly for airway remodeling. Herein, developing alternative and more effective therapy to attenuate remodeling is worthy of further study. Gu-Ben-Fang-X...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020711 | Pride
Rtn4 Pi3k/akt pathway Gu-ben-fang-xiao decoction Chronic remission asthma Airway remodeling 
Transcriptomics90 min Met4 hyperactivation ChIP-chip
Identification of in vivo binding targets of Met4 and Met32 by conducting chromatin immunoprecipitation studies using genomic tiling arrays (ChIP-on-chip 4X44K whole yeast genome arrays by Agilent) following 90 minutes Met4 hyperactivation.
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-21 | E-MEXP-3302 | biostudies-arrayexpress
GenomicsGenome wide binding of Insensitive in w[1118] embryos
ChIP-seq for Drosophila Insensitive, together with IgG control. Chromatin extracted from 2.5-6h w[1118] embryos and 6.5-12h w[1118] embryos. Samples from two time points were analyzed: 2.5-6h embryos and 6.5-12h embryos. In each time point there is one Insv ChIP sample and one IgG control sample.
ORGANISM(S): Drosophila melanogaster 
2013-04-04 | E-GEOD-44176 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of constitutively competent comR and proQ mutants and RNase R (rnr) mutant of L. pneumophila
Bacterial competence is a genetically programmed process that is triggered as a response to environmental stimuli. DNA uptake from the extracellular milieu by competence requires the expression of a complex machinery composed of a competence pseudopilus and a DNA translocase. In L. pneumophila, it ...
ORGANISM(S): Legionella pneumophila 
2010-05-20 | E-GEOD-12796 | biostudies-arrayexpress
UnknownInsulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.
Not available
S-EPMC3039328 | biostudies-literature
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
UnknownTargeted transcriptome analysis using synthetic long read sequencing uncovers isoform reprograming in the progression of colon cancer.
Not available
S-EPMC8079361 | biostudies-literature
ProteomicsHistone Kla is regulated by cellular glycolysis
We have identified a new histone modification, which is derived from glycolysis end product, lactate. By SILAC-MS/MS based quantification, and U-13C6 glucose labeling experiments, we demonstrate that histone Kla is regulated by cellular glycolysis pathway
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014870 | Pride
Human mcf-7 cells silac 
TranscriptomicsGene expression profile in mouse articular cartilage under normoxia (21% O2) and hypoxia (3% O2), with or without TIMP-3
RNAseq of mouse hip cartilage (hip caps) cultured for 44 hours in normoxia (21% O₂) or hypoxia (3% O₂), with or without 100 nM (2.6 µg/ml) recombinant human tissue inhibitor of metalloproteinases-3 (rhuTIMP-3) for the final 20 hours.
ORGANISM(S): Mus musculus 
2026-02-12 | E-MTAB-15388 | biostudies-arrayexpress
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