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UnknownTBL1X and Flot2 form a positive feedback loop to promote metastasis in nasopharyngeal carcinoma.
Not available
S-EPMC8771836 | biostudies-literature
TranscriptomicsGene expression studies to identify skeletal muscle genes related to stress in pigs
Expression profiles of porcine muscle Semimembranosus were studied to identify genes beeing significantly affected by pre-slaughter stress or no stress treatment in pigs of different breed (Italian Duroc, Italian Large White or Pietrain) and differnt Halothane genotype (RYR1 locus CC-NN, CT-Nn or TT...
ORGANISM(S): Sus scrofa 
2013-01-01 | E-GEOD-13115 | biostudies-arrayexpress
UnknownPlasma Proteomics to Identify Drug Targets for Ischemic Heart Disease.
Not available
S-EPMC10641761 | biostudies-literature
TranscriptomicsSuppression of Lung Adenocarcinoma Progression by Nkx2-1
Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-p...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26874 | biostudies-arrayexpress
TranscriptomicsNuclear TIGAR mediates an epigenetic-metabolic loop via Nrf2 for cancer therapeutics resistance
Epigenetic and metabolic reprogrammings are implicated in cancer progression with unclear mechanisms. We report here that the histone methyltransferase NSD2 drives cancer cell and tumor resistance to therapeutics such as tamoxifen, doxorubicin, and radiation by reprogramming of glucose metabolism. N...
ORGANISM(S): Homo sapiens 
2016-10-22 | E-GEOD-62613 | biostudies-arrayexpress
TranscriptomicsROR-γ drives androgen-receptor expression and represents a therapeutic target in castration-resistant prostate cancer
The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined. Here we show that retinoic acid receptor–related orphan receptor γ (ROR-γ) is overexpressed and amplifie...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-72483 | biostudies-arrayexpress
TranscriptomicsGNF mouse atlas_macrophages
Monocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we performed a systematic microarray analysis of GPCR expression in primary mouse tissues to identify family members that are either enriched in mac...
ORGANISM(S): Mus musculus 
2008-05-05 | E-GEOD-11339 | biostudies-arrayexpress
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