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We profiled the proteomics of prostate cancer (PCa) cell lines.
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-12-06 | PXD058635 |
We profiled the genome, transcriptome, proteome and phosphoproteome of 145 cases of localized prostate cancer (PCa) in Chinese patients and revealed three subtypes with distinct molecular features. We integrated multi-omic data to refine molecular subtyping of localized PCa, and identified NANS as a...
ORGANISM(S): Homo Sapiens 
2024-10-23 | PXD056748 |
The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined. Here we show that retinoic acid receptor–related orphan receptor γ (ROR-γ) is overexpressed and amplifie...
ORGANISM(S): Homo sapiens 
We profiled the proteomics of prostate cancer orthotopic transplanted mice.
ORGANISM(S): Mus Musculus 
2025-01-21 | PXD058636 |
Background and aim: Analysis of data obtained from genome wide gene expression experiments is challenging, due to the huge amount of variables, management of the data and the need for multivariate analysis. We here present the R package: pcaGoPromoter that facilitates the interpretation of genome wi...
ORGANISM(S): Homo sapiens 
We examine the role of Klf6 in oligodendrocyte progenitor cells and determine that Klf6 acts as a gp130-sensitive transactivator of the nuclear import factor importin-α5 (Impα5), a key controller of nuclear trafficking in oligodendrocytes. Examination of expression profiles of 2 different cell sta...
ORGANISM(S): Mus musculus 
We examine the role of Klf6 in oligodendrocyte progenitor cells and determine that Klf6 acts in part through direct regulation of gp130 signaling and nuclear import via importin-α5 (Impα5), a key controller of nuclear trafficking. Examination of Klf6 DNA binding in two different stages of differe...
ORGANISM(S): Mus musculus 
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