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Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
ProteomicsEIF4G2 Promotes HCC Progression
Aberrant translation from mRNAs to proteins plays a crucial role in the pathogenesis of various cancers. Here, we revealed that the key proteins involved in translation were up-regulated in two hepatocellular carcinoma (HCC) cohorts. Specifically, we identified the translation initiation factor EIF4...
ORGANISM(S): Homo Sapiens 
PXD052695 |
ProteomicsProteomic analysis of DEN and CCl4-induced hepatocellular carcinoma mouse model
DEN and CCl4-induced HCC mouse model was constructed, and the proteome of HCC and liver tissues was analyzed.
ORGANISM(S): Mus Musculus 
2024-02-04 | PXD049148 |
ProteomicsQuantitative proteomics revealed the mechanism of Yiqi Huoxue recipe used to treat cerebral infarction with Qi deficiency and blood stasis
Huoxue Yiqi (HXYQ) recipe is widely used to treat cerebral infarction with Qi deficiency and blood stasis syndrome (CI-QDBS), but its pharmacological mechanism is still not clear. In this study, the serum samples of patients with Qi deficiency and blood stasis syndrome in the convalescent stage of c...
ORGANISM(S): Homo Sapiens 
2022-12-12 | PXD029388 |
ProteomicsThe essential role of stress granules in cGAS sensing of DNA
cGAS-associated cellular proteins through performing co-immunoprecipitation (co-IP) followed by mass spectrometry and proteomic analysis
ORGANISM(S): Homo Sapiens 
2019-02-24 | PXD012847 |
UnknownPrevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study.
Not available
S-EPMC7880913 | biostudies-literature
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