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MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
MetabolomicsImpact of Diabetic Stress Conditions on Renal Cell Metabolome
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria. Subsequently, albuminuria can deteriorate the ...
2019-10-08 | MTBLS1093 | MetaboLights
TranscriptomicsExpression data from renal primary epithelial cells
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in the ADPKD genes PKD1 and PKD2 account for nearly all the cases of ADPKD. Increased cell prolif...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-11500 | biostudies-arrayexpress
TranscriptomicsRNA seq of fluid shear stress treated mouse renal epithelial cells
Renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized renal proximal tubular epithelial cell line. Cells were exposed to l...
ORGANISM(S): Mus musculus 
2018-03-15 | E-MTAB-6640 | biostudies-arrayexpress
Proteomicsmice Renal tubular epithelial cells LC-MS/MS
Diabetic nephropathy is considered one of the most common microvascular complications of diabetes and the pathophysiology involves multiple factors. Progressive diabetic nephropathy is believed to be related to the structure and function of the tubular epithelial cells in the kidney. However, the ro...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029651 | Pride
Mouse Renal tubular epithelial cells Lc-ms/ms 
TranscriptomicsRNA seq of fluid shear stress treated mouse Pkd1-/- renal epithelial cells
Pkd1-/- renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized Pkd1-/- renal proximal tubular epithelial cell line. Cells w...
ORGANISM(S): Mus musculus 
2019-03-01 | E-MTAB-6641 | biostudies-arrayexpress
MetabolomicsPathological glutaminolysis induces mitochondrial injury via OPA1 glutamylation in renal fibrosis

The promotion of repair in proximal renal tubular epithelial cells (PTEC) or the prevention of repair failure has been suggested as a beneficial strategy for mitigating the progression of chronic kidney disease (CKD). However, effective interventions to halt CKD progression and subsequent renal f...

2025-10-15 | MTBLS13145 | MetaboLights
MetabolomicsPathological glutaminolysis induces mitochondrial injury via OPA1 glutamylation in renal fibrosis

The promotion of repair in proximal renal tubular epithelial cells (PTEC) or the prevention of repair failure has been suggested as a beneficial strategy for mitigating the progression of chronic kidney disease (CKD). However, effective interventions to halt CKD progression and subsequent renal f...

2025-10-23 | MTBLS13148 | MetaboLights
ProteomicsUSP36-mediated deubiquitination of DOCK4 contributes to the diabetic renal tubular epithelial cell injury via Wnt/β-catenin signaling pathway
Diabetic kidney disease (DKD) has become the leading cause of end-stage renal diseases, but the efficacy of current treatment remains unsatisfactory. The pathogenesis of DKD needs a more in-depth research. Ubiquitin specific proteases 36 (USP36), a member of deubiquitinating enzymes family, has arou...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023347 | Pride
Dedicator of cytokinesis 4 Deubiquitination Epithelial-to-mesenchymal transition Diabetic kidney disease Ubiquitin specific proteases 36 Wnt/β-catenin 
TranscriptomicsTubular epithelial cells cisplatin and EPC EVs apoptosis
Renal tubular epithelial cells were treated with cisplatin in presence or absence of EPC-derived EVs
ORGANISM(S): Homo sapiens 
2013-09-30 | E-MEXP-3981 | biostudies-arrayexpress
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