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ProteomicsEquine muscle-derived mesenchymal stem cells protect cartilage explants in osteoarthritis model: secretome characterization
Background: Osteoarthritis is a highly prevalent joint degenerative disease for which therapeutic treatments are limited or invasive. Cell therapy based on mesenchymal stem/stromal cells (MSCs) is therefore seen as a promising approach for this disease, in both human and horses. Objective: As the r...
ORGANISM(S): Equus caballus (Horse) 
2022-11-08 | PXD031924 | Pride
Stem cells  equine Secretome 
ProteomicsEndogenous TOM20 proximity labelling: a Swiss-knife for the study of mitochondrial proteins in human cells
The majority of mitochondrial proteins are encoded by the nuclear genome and must be imported into the mitochondria. There are two main paths for mitochondrial protein import: post-translational and co-translational import. Co-translational import couples the translation and the translocation of the...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD038821 | Pride
Mitochondria  co-translational import  bioid  protein identification  mass spectrometry 
ProteomicsThe global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation
Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation both at the global and transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic differentiation of induced pluripotent stem cells (iPSCs) by pol...
ORGANISM(S): Homo sapiens (Human) 
2022-12-26 | PXD038204 | Pride
Translational regulation Top mrna Hepatocyte differentiation Stem cells 
TranscriptomicsMPV17 does not control cancer cell proliferation
MPV17 is described as a mitochondrial inner membrane channel. Although its function remains elusive, mutations in the MPV17 gene results in hepato-cerebral mitochondrial DNA depletion syndrome. However, in this study, we show that MPV17 silencing does not induce depletion in mitochondrial DNA conten...
ORGANISM(S): Homo sapiens 
2019-08-01 | E-MTAB-8108 | biostudies-arrayexpress
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