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TranscriptomicsMicroarray analysis of human NK cells following oncolytic reovirus treatment of peripheral blood mononuclear cells (PBMC)
Oncolytic viruses (OV) kill tumour cells directly and induce anti-tumour immunity. We analysed gene expression profiles in human NK cells following treatment of PBMC with oncolytic reovirus in vitro.
ORGANISM(S): Homo sapiens 
2022-01-03 | E-MTAB-9826 | biostudies-arrayexpress
GenomicsGrass carp reovirus strain:873
Grass carp reovirus(GCRV) circRNAs Raw sequence reads
PRJNA613422 | ENA
ProteomicsAffinity-purified interactants of reovirus muNS
Mammalian orthoreovirus (reovirus) nonstructural protein μNS nucleates viral factories (VFs), which are sites of viral genome replication, protein synthesis, and particle assembly. Reovirus mRNAs are not polyadenylated, yet these transcripts are efficiently translated. To identify host factors assoc...
ORGANISM(S): Mammalian orthoreovirus 3 Dearing Homo sapiens (Human) 
2025-11-24 | PXD069183 | Pride
ProteomicsQuantitative Proteome Responses to Oncolytic Reovirus in GM-CSF and M-CSF-Differentiated Bone Marrow-Derived Cells
To explore reovirus-macrophage interactions, we performed tandem mass tag (TMT)-based quantitative temporal proteomics on mouse bone marrow-derived macrophages (BMMs) generated with 2 cytokines, M-CSF and GM-CSF, representing anti- and pro-inflammatory macrophages, respectively. We quantified 6,863 ...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-07 | PXD015203 | Pride
Reovirus Cell differentiation Macrophages Oncolytic viruses Antigen presentation/processing Viral defense Quantitative proteomics Anti-viral immune response 
TranscriptomicsPeroxisomes are signaling patforms for antiviral innate immunity
Analysis of the transcriptional response of mouse embryonic fibroblasts to reovirus infection. The hypothesis tested was that both peroxisomal and mitochondrial MAVS is capable of inducing the expression of antiviral genes. mRNA isolated from MAVS-expressing cells after infection for various times ...
ORGANISM(S): Mus musculus 
2010-11-04 | E-GEOD-21215 | biostudies-arrayexpress
ProteomicsAnnexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and regulates formation of reovirus factories
Early in infection, mammalian orthoreoviruses (reoviruses) build neo-organelles called viral factories (VFs). These structures incorporate fragments of endoplasmic reticulum (ER) and serve as sites of viral genome replication and particle assembly. Two reovirus nonstructural proteins, σNS and µNS, r...
ORGANISM(S): Reovirus sp. Homo sapiens (Human) 
2025-10-29 | PXD067290 | Pride
Reovirus Σns Endoplasmic reticulum Actin Viral factories Annexin a2 Μns 
GenomicsCallinectes sapidus reovirus 1
Callinectes sapidus reovirus 1
PRJNA939818 | ENA
ProteomicsReshaping of the MHC-I ligandome in response to reovirus-based cancer immunotherapy
Oncolytic viruses (OVs), known for their cancer-killing characteristics, overturn tumor-associated defects in antigen presentation through the MHC class I pathway and induce protective neo antitumor CD8 T cell responses. Nonetheless, whether OVs shape the tumor MHC-I ligandome remains unknown. Here,...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-20 | PXD013066 | Pride
Antitumor immunity Reovirus Mhc ligandome Mass spectrometry Cancer immunotherapy Cd8 t cell epitopes Oncolytic virus 
GenomicsReovirus low-density particles package viral and cellular RNA
Reovirus low-density particles package viral and cellular RNA
PRJNA689770 | ENA
GenomicsTranscriptome Signature Post Reovirus Treatment In KRAS Mutated Colorectal Cancer
Transcriptome Signature Post Reovirus Treatment In KRAS Mutated Colorectal Cancer
PRJNA726514 | ENA
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