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TranscriptomicsA conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing [sRNA-seq]
Co-transcriptional RNA processing and surveillance factors mediate heterochromatin formation in fission yeast. In addition to RNAi, RNA elimination machinery including MTREC (Mtl1-Red1 core) and the exosome are involved in facultative heterochromatin assembly, however, the exact mechanisms remain un...
ORGANISM(S): Schizosaccharomyces pombe 
2016-01-05 | E-GEOD-74739 | biostudies-arrayexpress
TranscriptomicsSpt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe
Spt6 is a conserved factor, critically required for several transcription and chromatin related processes. We now show that Spt6 and its binding partner, Iws1, are required for heterochromatic silencing in Schizosaccharomyces pombe. Our studies demonstrate that Spt6 is required for silencing of al...
ORGANISM(S): Schizosaccharomyces pombe 
2011-10-20 | E-MTAB-738 | biostudies-arrayexpress
TranscriptomicsArgonaute proteins couple chromatin silencing to alternative splicing
This SuperSeries is composed of the following subset Series: GSE39746: Argonaute proteins couple chromatin silencing to alternative splicing (exon array) GSE39748: Argonaute proteins couple chromatin silencing to alternative splicing (RNA IP-Seq) Refer to individual Series
ORGANISM(S): Mus musculus 
2012-08-22 | E-GEOD-39749 | biostudies-arrayexpress
TranscriptomicsRelics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa
Both RNAi-dependent and -independent mechanisms have been implicated in the establishment of heterochromatin domains, which may be stabilized by feedback loops involving chromatin proteins and modifications of histones and DNA. Neurospora crassa sports features of heterochromatin found in higher eu...
ORGANISM(S): Neurospora crassa 
2010-05-15 | E-GEOD-12690 | biostudies-arrayexpress
TranscriptomicsMobile 24 nt small RNAs direct transcriptional gene silencing in the root meristems of Arabidopsis thaliana
We grafted Transcriptional Gene Silencing (TGS)-inducing wild type Arabidopsis and a mutant that is compromised in 24 nucleotide (nt) small RNA (sRNA) production onto a wild type reporter line. We observed that 21-24 nt sRNAs were transmitted across a graft union yet only the 24 nt sRNAs directed RN...
ORGANISM(S): Arabidopsis thaliana 
2011-10-23 | E-GEOD-31651 | biostudies-arrayexpress
TranscriptomicsRequirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis
As a central component during Okazaki fragment maturation, flap endonuclease 1 (FEN1) removes the 5’ flap and maintains genomic stability. Here, FEN1 was cloned as a suppressor of transcriptional gene silencing (TGS) from a forward genetic screen. FEN1 is abundant in the root and shoot apical meri...
ORGANISM(S): Arabidopsis thaliana 
2016-05-28 | E-GEOD-79738 | biostudies-arrayexpress
TranscriptomicsTranscriptional gene silencing mediated by interplay of MOM1 and Pol V
In plants, multiple levels of epigenetic control suppress transposon movement and permit somatic as well as transgenerational transmission of gene expression patterns. A variety of factors are involved that establish and/or maintain epigenetic marks, such as covalent modification of DNA and histones...
ORGANISM(S): Arabidopsis thaliana 
2010-06-19 | E-GEOD-17940 | biostudies-arrayexpress
TranscriptomicsArgonaute proteins couple chromatin silencing to alternative splicing (RNA IP-Seq)
While Argonaute (AGO) proteins play a major role in transcriptional gene silencing (TGS) in many organisms, their role in the nucleus of somatic mammalian cells remains elusive. Here, we have purified AGO1 and AGO2 chromatin-embedded complexes, and found these proteins associated with previously des...
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39748 | biostudies-arrayexpress
TranscriptomicsArgonaute proteins couple chromatin silencing to alternative splicing (exon array)
While Argonaute (AGO) proteins play a major role in transcriptional gene silencing (TGS) in many organisms, their role in the nucleus of somatic mammalian cells remains elusive. Here, we have purified AGO1 and AGO2 chromatin-embedded complexes, and found these proteins associated with previously des...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-39746 | biostudies-arrayexpress
TranscriptomicsTranscriptional gene silencing by Arabidopsis Microrchidia homologues involves the formation of heteromers
Epigenetic gene silencing is of central importance to maintain genome integrity and is mediated by an elaborate interplay between DNA methylation, histone posttranslational modifications and chromatin remodeling complexes. DNA methylation and repressive histone marks usually correlate with transcrip...
ORGANISM(S): Arabidopsis thaliana 
2014-06-01 | E-GEOD-54677 | biostudies-arrayexpress
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