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MetabolomicsAMPK activation orchestrated replicative senescence of periodontal ligament stem cells via regulating metabolomics

BACKGROUND: Periodontal ligament mesenchymal stem cells (PDLSCs) are a promising cell resource for cell-based regenerative medicine in dentistry. PDLSCs inevitably acquire a senescent phenotype after prolonged in vitro expansion, and the key regulators of cells during replicative...

2022-11-15 | MTBLS4568 | MetaboLights
TranscriptomicsTranscriptomics of human IMR90 model of replicative senescence
The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. We employ transcriptomics (alongside proteomics) to determine changes at the mRNA and protein levels, ...
ORGANISM(S): Homo sapiens 
2026-07-16 | E-MTAB-15914 | biostudies-arrayexpress
GenomicsYeast transcriptome profiling in replicative ageing
Yeast transcriptome profiling in replicative ageing
PRJEB9510 | ENA
TranscriptomicsPathway Profiling of Replicative and Induced Senescence
RNA-seq was performed on LFS MDAH041 cells that were young (PD10-12), aging (PD17-19) and replicatively senescent (PD28-30), as well as spontaneously immortal cells and cells that were induced into senescence or quiescence, in order to profile the pathways common in all 4 types of sensecence and th...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-60340 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mammary epithelial cells HMECs in replicative senescence vs fibroblasts
Telomere shortening in populations of human mammary epithelial cells (HMECs) that survive early replicative arrest (M0) by the inactivation of p16INK4A during cell culture on plastic dishes leads to a state of permanent replicative arrest termed senescence. While culture of HMECs on feeder layers ab...
ORGANISM(S): Homo sapiens 
2005-11-01 | E-SMDB-2210 | biostudies-arrayexpress
ProteomicsAlterations in proteome and proteostasis networks during replicative senescence
The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. Despite this, our knowledge about the molecular, spatial and temporal changes that drive aging on a ce...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD077854 | Pride
Sumo2/3-modified proteome Replicative senescence Imr90 model 
ProteomicsAlterations in proteome and proteostasis networks during replicative senescence
The accumulation of senescent cells constitutes a pivotal hallmark of tissue ageing, contributing to disruption of tissue homeostasis and thus, to the development of several aging-related diseases. Despite this, our knowledge about the molecular, spatial and temporal changes that drive aging on a ce...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD069123 | Pride
Solubility Replicative senescence 
GenomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites (MBD-seq)
Primary cells enter replicative senescence after a limited number of cell divisions. This process is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains unknown and may arise through drif...
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59960 | biostudies-arrayexpress
TranscriptomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites (RNA-seq)
Primary cells enter replicative senescence after a limited number of cell divisions. This process is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains unknown and may arise through drif...
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59966 | biostudies-arrayexpress
TranscriptomicsThe Senescent Methylome and its relationship with cancer, ageing, and germline genetic variation in humans (gene expression)
Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. However, till now, biological markers that define senescence on a genome-wide scale have been limited. Here, we report a DNA meth...
ORGANISM(S): Homo sapiens 
2015-07-26 | E-GEOD-56718 | biostudies-arrayexpress
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