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MetabolomicsTroubleshooting in Large-Scale LC-ToF-MS Metabolomics Analysis: Solving Complex Issues in Big Cohorts
Metabolomics, understood as the science that manages the study of compounds from the metabolism, is an essential tool for deciphering metabolic changes in disease. The experiments rely on the use of high-throughput analytical techniques such as liquid chromatography coupled to mass spectrometry (LC-...
2019-12-12 | MTBLS1133 | MetaboLights
ProteomicsAddressing reproducibility challenges in cell culture: the impact of oxylipins contained in fetal calf serum
Reproducibility issues regarding complex in vitro cell culture experiments have been mainly attributed to genetic variations within cell lines. Batch-dependent fetal calf serum variations are well known and also represent relevant influencing factors. However, the molecular constituents mediating su...
ORGANISM(S): Homo sapiens (Human) 
2021-06-01 | PXD020617 | Pride
Eicosanoids Macrophages Reproducibility issues Cell metabolism 
ProteomicsPilot evaluation of long-term reproducibility of capillary zone electrophoresis-tandem mass spectrometry for top-down proteomics of a complex proteome sample
In this work, for the first time, we performed a pilot investigation of long-term reproducibility of CZE-MS for TDP of a complex sample (i.e., a yeast cell lysate) to achieve a better understanding of advantages, issues and potential solutions of CZE-MS for large-scale TDP.
ORGANISM(S): Candida albicans (Yeast) Saccharomyces cerevisiae 
2024-03-20 | PXD046651 | Pride
Yeast proteome Capillary zone electrophoresis-tandem ms (cze-ms/ms) Top-down proteomics (tdp) Capillary cleanup Long-term reproducibility 
UnknownScientific integrity issues in Environmental Toxicology and Chemistry: Improving research reproducibility, credibility, and transparency.
Not available
S-EPMC7313240 | biostudies-literature
UnknownReprocessing 16S rRNA Gene Amplicon Sequencing Studies: (Meta)Data Issues, Robustness, and Reproducibility.
Not available
S-EPMC8566820 | biostudies-literature
UnknownCountering reproducibility issues in mathematical models with software engineering techniques: A case study using a one-dimensional mathematical model of the atrioventricular node.
Not available
S-EPMC8289093 | biostudies-literature
Methylation profilingProtocol matters – reproducibility and rigor of DNA methylation data sets [BiSulfite-seq]
While epigenetics continues to be a burgeoning research area in neuroscience, unaddressed issues related to data reproducibility across laboratories remain. Indeed, separating meaningful experimental changes from background variability is a challenge in epigenomic studies. Genome-wide DNA methylatio...
ORGANISM(S): Rattus norvegicus 
2022-01-12 | GSE164831 | GEO
TranscriptomicsProtocol matters – reproducibility and rigor of DNA methylation data sets [RNA-seq]
While epigenetics continues to be a burgeoning research area in neuroscience, unaddressed issues related to data reproducibility across laboratories remain. Indeed, separating meaningful experimental changes from background variability is a challenge in epigenomic studies. Genome-wide DNA methylatio...
ORGANISM(S): Rattus norvegicus 
2022-01-12 | GSE164800 | GEO
UnknownHPRep: Quantifying Reproducibility in HiChIP and PLAC-Seq Datasets.
Not available
S-EPMC8929028 | biostudies-literature
TranscriptomicsComparison of microarray platforms for measuring differential microRNA expression (Agilent data)
Microarray technology applied to miRNA profiling is a promising tool in many research fields. At present, only few studies have addressed intra- and inter-platform reproducibility by using tissues/cell-lines of different origin to maximize differences in miRNA content. Although the approach might pr...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-33124 | biostudies-arrayexpress
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