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MetabolomicsRepurposing statins and phenothiazines to treat chemoresistant neuroblastoma

Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurpos...

2025-11-13 | MTBLS13246 | MetaboLights
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
MetabolomicsCell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle since the insect stage utilizes the cost-effective oxidative phosphorylation to generate ATP, while bloodstream cells switch to less energetically efficient aerobic glycolysis. Due to difficulties in a...

2020-08-20 | MTBLS1390 | MetaboLights
MetabolomicsMetabolite profiling of Malaysian Gracilaria edulis reveals Eplerenone as novel antibacterial compound for drug repurposing against MDR Bacteria
Not available
ORGANISM(S): Gracilaria edulis 
ST001839 | MetabolomicsWorkbench
UnknownA Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics.
Not available
S-EPMC12679946 | biostudies-literature
ProteomicsDiscovering the N-terminal Methylome by the Repurposing of Proteomic Datasets
Protein ⍺-N-methylation is a cryptic and relatively unexplored post-translational modification involving the covalent addition of methyl groups to the free a-amino group at protein N-termini. To systematically explore the extent of ⍺-N-terminal methylation in yeast and humans, we utilized a repurpos...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-05-26 | PXD022833 | Pride
Proteomics Post-translational modification Repurposing ⍺-n-terminal methylation 
GenomicsRepurposing of promoters and enhancers during mammalian evolution
Repurposing of promoters and enhancers during mammalian evolution
PRJNA470431 | ENA
GenomicsRepurposing clofarabine against enteric pathogens via metabolic starvation
Repurposing clofarabine against enteric pathogens via metabolic starvation
PRJNA1527417 | ENA
ProteomicsRepurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology
Drug repurposing offers a cost-effective strategy for accelerating therapeutic development. This study identifies trazodone, an FDA-approved anti-depressant, as a promising therapeutic candidate for Alzheimer’s disease (AD). We show that trazodone use in patients with AD is associated with decreased...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-02 | PXD071776 | Pride
GenomicsSystems immunology-based drug repurposing framework to target inflammation in atherosclerosis [RNA-seq_PBMC]
Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis [RNA-seq_PBMC]
PRJNA957897 | ENA
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