Resistance mechanisms

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Axon- GenePix4000B (3)
Illumina Genome Analyzer II (3)
Illumina HiSeq 3000 (3)
Tru-cut biopsy needle (Marquee®, 16 G × 10 cm) (2)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
. (2)
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418 [Affymetrix] (2)
ScanArray Express HT [PerkinElmer] (2)
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Applied BiosystemsTM GeneChipTM Whole Transcript (WT) PLUS Reagent Kit User Guide (Thermo Fisher Scientific, Waltham, MA, USA). (1)
Applied BiosystemsTM GeneChipTM Clariom S human arrays (1)
PAXgene Blood RNA Kit (PreAnalytiX, Hombrechtikon, Switzerland). (1)
TruSeq PCR-free Sample Preparation Kit (1)
Coulter Automated Workstation Biomek i7 Hybrid (1)

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UNIPROT ID/AC

P35568 (5)
P42345 (4)
Q6R327 (3)
Q8N122 (3)
P31751 (3)
Q02750 (3)
P04049 (3)
P01112 (3)
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P05230 (2)
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P01308 (2)
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O14920 (2)
P00533 (2)
P62993 (2)

ENSEMBL ID

ENSG00000170477 (56)
ENSG00000147251 (1)

CHEBI ID

CHEBI:16027 (14)
CHEBI:17234 (9)
CHEBI:15422 (8)
CHEBI:17822 (8)
CHEBI:17553 (8)
CHEBI:16761 (8)
CHEBI:16908 (7)
CHEBI:15846 (7)
CHEBI:17552 (7)
CHEBI:36080 (4)
CHEBI:72738 (1)
CHEBI:74707 (1)
CHEBI:63637 (1)
CHEBI:75047 (1)
CHEBI:79091 (1)
CHEBI:35222 (1)
CHEBI:30413 (1)
CHEBI:16618 (1)
CHEBI:17489 (1)
CHEBI:15367 (1)
CHEBI:48153 (1)
CHEBI:16905 (1)
CHEBI:15946 (1)
CHEBI:17138 (1)
CHEBI:15343 (1)
CHEBI:15996 (1)
CHEBI:16474 (1)
CHEBI:18009 (1)
CHEBI:16526 (1)
CHEBI:30031 (1)

Metabolite Name

Uridine (22)
Guanosine (21)
Adenosine (20)
L-Phenylalanine (20)
Hypoxanthine (19)
Thymine (18)
L-Proline (18)
L-Tryptophan (18)
L-Glutamine (18)
Cytidine (17)
Creatine (17)
L-Tyrosine (17)
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L-Arginine (16)
Citric acid (16)
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Thymidine (16)
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L-Threonine (15)
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L-Valine (15)
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Succinic acid (14)
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Sucrose (14)
L-Isoleucine (14)
Glycine (13)

First Public Date

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2012 (3)
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Modelling Approach

Ordinary differential equation model (18)
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Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (9)
Moffitt Cancer Center Tampa, FL, USA (7)
Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia (5)
Department of Molecular Cell Biology, Weizmann institute of Science, Israel (5)
Proteomics facility, Central Science Laboratory, University of Tasmania (4)
Thoracic Oncology Moffitt Cancer Center Tampa, FL, USA (4)
Thoracic Oncology Molecular Medicine Program Moffitt Cancer Center Tampa, FL, USA (4)
Basic Immune System of Plants / Protein Mass Spectrometry Max Planck Institute for Plant Breeding Research Carl-von-Linne-Weg 10, 50829 Cologne, Germany (3)
Chair of Proteomics and Bioanalytics Technical University of Munich Emil-Erlenmeyer-Forum 5 85354 Freising Germany (3)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (3)
Department of Comparative Biochemistry and Bioanalytics Faculty of Biochemistry, Biophysics and Biotechnology Jagiellonian University in Krakow (3)
Drug Discovery Moffitt Cancer Center Tampa, FL, USA (3)
GlycoProteomics Laboratory, Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Lineu Prestes 1374, CEP 05508-000, Sao Paulo, Brazil (3)
Molecular Genetics, RPTU Kaiserslautern (3)
Molecular and Cellular Biology, University of Guelph, Canada (3)
Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia (3)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (3)
Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field, Ministry of Education, Harbin 150040, China (2)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (2)
Biochemistry (2)
College of Horticulture, Northwest A&F University (2)
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China (2)
Crown Bioscience (2)
Department of Molecular Biology and Radiobiology, Mendel University in Brno, CZ (2)
Department of Molecular Biosciences, University of South Florida, Tampa, FL, USA Center for Antimicrobial Resistance, University of South Florida, Tampa, FL, USA (2)
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany (2)
Division of Surgery, Oncology, and Pathology, Department of Clinical Sciences, Lund University, Solvegatan 19, 223 62, Lund, Sweden. (2)
First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (2)
Functional Proteomics Laboratory, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, India (2)
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Keyword

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Not yet available (1)
NIS793 (1)
Transforming growth factor βeta (TGF-β) (1)
Anti PD-1 monoclonal antibody (1)
Mechanisms of acquired resistance (1)
Anti-EGFR therapy (1)
Detection of the emergence of RAS mutations (1)
Circulating DNA in patients (1)
Treatment with anti-EGFR therapy (1)
NK cell therapy (1)
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Cellular therapy (1)
Circulating cell free DNA (1)
Muscle strength (1)
Cardiorespiratory fitness (1)
Chemotherapy dose modification (1)
Progression free survival (1)
Bayesian adaptive trial (1)
Checkpoint Inhibitor (1)

IsPrivate

False (29)

Model Flag

Non Kinetic (2)

Submitter Keywords

Immuno-oncology (4)
Not Peer Reviewed (2)
FROG (2)
Machine Learning Model (1)
Manuscript Accepted (1)

Classification

bacteria (664)
fungi (65)
protozoa (21)
viruses (8)
helminths (2)

Modification

2x(15)N labeled L-lysine (4)
57.021464 (3)
-17.026549 (2)
15.994915 (2)
42.010565 (2)
4x(15)N labeled L-arginine (2)
56.026215 (2)
59.036279 (2)
-18.010565 (1)
15.99491 (1)
27.994915 (1)
31.989829 (1)
57.02146 (1)
N6 (1)
Not available (1)

Study type

Transcription profiling by array (1536)
RNA-seq of coding RNA (284)
ChIP-seq (112)
RNA-seq of non coding RNA (66)
Unknown experiment type (50)
Comparative genomic hybridization by array (45)
ChIP-chip by tiling array (36)
Other (32)
Methylation profiling by array (32)
RNA-seq of coding RNA from single cells (23)
RNA-seq of total RNA (17)
DNA-seq (13)
Methylation profiling by high throughput sequencing (13)
ChIP-chip by array (9)
Cell line - High-throughput sequencing (7)
Transcription profiling by RT-PCR (7)
Proteomic profiling by array (7)
Genotyping by array (6)
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Animal - High-throughput sequencing (4)
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Ribo-seq (3)
Human - One-color microarray (2)
Transcription profiling by tiling array (2)
RNAi profiling by array (2)
CLIP-seq (2)
Hi-C (2)

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2002 (35)
2003 (34)
2000 (27)
2001 (26)
1999 (12)
1998 (11)
1997 (4)

Location

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France (4)
Italy (3)
Canada (3)
Spain (2)
Germany (2)
Netherlands (2)
United States (2)
Saudi Arabia (1)
Hong Kong (1)
Singapore (1)
Taiwan (1)
Israel (1)
Hungary (1)
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United Kingdom (1)
South Korea (1)
Japan (1)
Czechia (1)
Switzerland (1)

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Metabolomic and Transcriptomic Analysis of Drought Resistance Mechanisms in Sorghum Varieties

This study explored the drought resistance of sorghum through metabolomics and transcriptomics analysis. Screening drought tolerant variety GL220 and drought sensitive variety GL98 revealed significant differences in metabolite and gene expression under drought conditions. Through database annotatio...

2025-05-29 | MTBLS11479 | MetaboLights

Metabolome and transcriptome combined profiling reveals fluconazole resistance mechanisms of Trichosporon asahii and role of farnesol in fluconazole tolerance

Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few studies have explored the underlying mec...

2023-11-20 | MTBLS7236 | MetaboLights

Integrated analysis of therapeutic efficacy and resistance mechanisms of lytic phages targeting ST218 K57 CR-hvKp

Clinical infection caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is gradually increasing and spreading across the world, and phage therapy is a viable application as an alternative to antibiotics. However, additional clinical application is still restricted by the phag...

2025-09-18 | MTBLS12480 | MetaboLights

Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum

The emergence of multi-drug resistant Plasmodium falciparum underscores the urgent need for new antimalarial therapies. SC83288, a novel chemical entity, is highly effective against P. falciparum both in vivo and in vitro, including strains resistant to artemisinin and partner drugs. Here, we sho...

2026-02-16 | MTBLS13911 | MetaboLights

Molecular Basis Underlying Common Cutworm Resistance of the Primitive Soybean Landrace Peking

The common cutworm (CCW; Spodoptera litura) is one of the major insect pests of soybean in Asia and Oceania. Although quantitative trail loci related to CCW resistance have been introduced into leading soybean cultivars, these do not exhibit sufficient resistance against CCW. Thus, under...

2020-11-06 | MTBLS1960 | MetaboLights

Mechanisms for Insulin Resistance in Polycystic Ovary Syndrome with metformin therapy: aminoadipic acid, lysine concentrations, and enrichment (part I)

Not available

ORGANISM(S): Homo sapiens

ST000947 | MetabolomicsWorkbench

Mechanisms of Iprovalicarb and Cycluron in Promoting Conjugative Transfer of Antibiotic Resistance Genes and Outer Membrane Vesicle-Mediated Dissemination

Detect pesticide residues in water, manure, and soil from waterfowl farms.

2026-08-07 | MTBLS15288 | MetaboLights

Osh2 mediates Candida resistance to miltefosine by regulating zymosterol transport

Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...

2025-07-03 | MTBLS12270 | MetaboLights

Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity

Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...

2018-04-26 | MTBLS582 | MetaboLights

Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a

Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment with P. distasonis improves IR, strengthens intestinal integrity, and reduces ...

2023-11-01 | MTBLS7943 | MetaboLights