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TranscriptomicsGene expression signatures of symptomatic respiratory viral infection in adults
Diagnosis of acute respiratory viral infection is currently based on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis. We used microarrays to capture p...
ORGANISM(S): Homo sapiens 
2009-08-06 | E-GEOD-17156 | biostudies-arrayexpress
MetabolomicsImmunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...
2023-05-02 | MTBLS5288 | MetaboLights
MetabolomicsMapping of the viral shunt across widespread coccolithophore blooms using metabolic biomarkers

The viral shunt is a fundamental ecosystem process which diverts the flux of organic carbon fixed through photosynthesis during algal bloom events from heterotrophic grazers to bacteria. Through the extracellular release of metabolites, lytic viral infections supply 2-10% of photosynthetically fi...

2025-10-08 | MTBLS11597 | MetaboLights
MetabolomicsDIVA Metabolomics: Differentiating Vaccination Status Following Viral Challenge Using Metabolomic Profiles
This study employed metabolomic profiling technologies, to identify metabolites (small molecules) in blood which are found at different levels in vaccinated compared to non-vaccinated animals exposed to virus.
2018-07-13 | MTBLS456 | MetaboLights
MetabolomicsNMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection

Sepsis, defined as life-threatening organ dysfunction caused by infection is difficult to distinguish clinically from infection or post-operative inflammation. We hypothesized that in a heterogeneous group of critically ill children, there would be different metabolic profiles between post-operat...

2020-11-19 | MTBLS563 | MetaboLights
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
TranscriptomicsVitamin A-deficient mice experience increased viral antigens and enhanced cytokine/chemokine production in nasal tissues following respiratory virus infection despite the presence of FoxP3+ T cells
Vitamin A deficiencies and insufficiencies affect hundreds of millions of people in both developing and developed countries. These individuals experience higher rates of mortality and increased morbidity during enteric and respiratory infections compared to those who are vitamin A sufficient. Previo...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-65805 | biostudies-arrayexpress
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
MetabolomicsMetabolic profiling of Candida clinical isolates of different species and infection sources

Candida species are the most common cause of opportunistic fungal infections. Rapid identification and novel approaches for the characterization of these fungi are of great interest to improve the diagnosis and the knowledge about their pathogenic properties. This study aimed to characte...

2024-07-09 | MTBLS1978 | MetaboLights
TranscriptomicsmicroRNA-mediated GALNT3 upregulation facilitates mucin production and viral replication in influenza A virus-infected respiratory epithelial cells
Viral infections affecting the upper or lower respiratory tract induce mucin production in the epithelial surfaces of the respiratory cells. However, a little is known about how mucins are produced on the surfaces of respiratory epithelial cells and affects viral replication. In the course of the in...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-57508 | biostudies-arrayexpress
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