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MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
MetabolomicsImmunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...
2023-05-02 | MTBLS5288 | MetaboLights
TranscriptomicsGene expression signatures of symptomatic respiratory viral infection in adults
Diagnosis of acute respiratory viral infection is currently based on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis. We used microarrays to capture p...
ORGANISM(S): Homo sapiens 
2009-08-06 | E-GEOD-17156 | biostudies-arrayexpress
MetabolomicsLipidomics analysis of oviducts from infectious bronchitis virus-infected chicks

Avian infectious bronchitis virus (IBV), a highly pathogenic  gammacoronavirus , causes severe respiratory and urogenital system disease in chickens, resulting in huge economic losses in global poultry production.  This study employs lipidomics analysis to comp...

2025-10-15 | MTBLS12744 | MetaboLights
MetabolomicsMetabolomics analysis of oviducts from infectious bronchitis virus-infected chicks

Avian infectious bronchitis virus (IBV), a highly pathogenic  gammacoronavirus , causes severe respiratory and urogenital system disease in chickens, resulting in huge economic losses in global poultry production.  This study employs metabolomics analysis to co...

2025-10-15 | MTBLS12740 | MetaboLights
MetabolomicsIntegrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism
Pandemic influenza viruses modulate pro-inflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Int...
2016-05-11 | MTBLS196 | MetaboLights
MetabolomicsMicroRNA-mediated regulation of lipid metabolism in virus-infected Emiliania huxleyi.
The interactions between Emiliania huxleyi and E. huxleyi virus (EhV) regulate marine carbon and sulfur biogeochemical cycles and play a prominent role in global climate change. As a large DNA virus, EhV has developed a novel 'virocell metabolism' model to meet its high metabolic needs. Although it ...
2024-01-16 | MTBLS5178 | MetaboLights
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
ProteomicsBovine Respiratory Disease Complex
Bovine respiratory epithelial cells have different susceptibility to bovine respiratory syncytial virus infection. The cells derived from the lower respiratory tract were significantly more susceptible to the virus than those derived from the upper respiratory tract. Pre-infection with virus of lowe...
ORGANISM(S): Bos Taurus 
2020-07-28 | PXD019509 | JPOST Repository
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