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MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
TranscriptomicsMolecular reprogramming of primary human resting memory CD4+ T cells by HIV-1 Vpr
Resting CD4+ T cells are infected by HIV-1 in vivo, however are refractory to cell-free HIV-1 infection in vitro. We show that they are efficiently infected by cell-to-cell spread. To allow resting T cell infection, uninfected resting target cells were co-cultured with infected donor T cells. Cells ...
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-11454 | biostudies-arrayexpress
TranscriptomicsResting versus activated T cells
miRNA profiling of resting and activated T cells Two condition experiment, resting versus activated T cells, measured pooled samples from three independent stimulations
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-21753 | biostudies-arrayexpress
TranscriptomicsImmune response eQTL study in human neonatal myeloid cells and T cells
Gene expression microarray data in resting myeloid cells and CD4+ T cells, as well as in response to lipopolysaccharide (LPS) or phytohemagglutinin (PHA) stimulation for 24 hours, respectively. Myeloid cells and CD4+ T cells were purified from resting and stimulated peripheral blood mononuclear cell...
ORGANISM(S): Homo sapiens 
2020-04-20 | E-MTAB-8977 | biostudies-arrayexpress
TranscriptomicsIdentification of the Early VIP Transriptome and its Associated Interactome in Resting Murine CD4 T Cells
Identification of the Early Vasoactive Intestinal Peptide (VIP) Transriptome and its Associated Interactome in Resting Murine CD4 T Cells In an attempt to understand the biological role of this neuropeptide in the immune system, we choose CD4 T cells as a cellular system for identifying a VIP-indu...
ORGANISM(S): Mus musculus 
2010-01-09 | E-GEOD-18524 | biostudies-arrayexpress
TranscriptomicsThe role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells
BACKGROUND: Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+ T-cells remain unclear. Previously...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-70106 | biostudies-arrayexpress
TranscriptomicsIdentification of the Early VIP Transriptome and its Associated Interactome in Resting and Activated Murine CD4 T Cells
This SuperSeries is composed of the following subset Series: GSE18524: Identification of the Early VIP Transriptome and its Associated Interactome in Resting Murine CD4 T Cells GSE18525: Identification of the Early VIP Transriptome and its Associated Interactome in Activated Murine CD4 T Cells Refer...
ORGANISM(S): Mus musculus 
2010-01-09 | E-GEOD-18526 | biostudies-arrayexpress
ProteomicsA proteomic map of resting and activated CD4+ T cells
CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of different immune cells. They are known to play crucial roles in antibody class switching in B cells, neutrophil recruitment and activation of macrophages and CD8+ cytotoxic T cells. ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-18 | PXD021250 | Pride
Mass spectrometry Cd4+ t helper cells T lymphocytes Label-free quantitation Systems biology Adaptive immunity 
TranscriptomicsMiRNome and transcriptome aided pathway analysis in human regulatory T cells
Owing to their manifold immune regulatory functions, regulatory T cells (Treg) have received tremendous interests as targets for therapeutic intervention of diverse immunological pathologies or cancer. Directed manipulation of Treg will only be achievable with extensive knowledge about the intrinsic...
ORGANISM(S): Homo sapiens 
2014-05-23 | E-GEOD-54953 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of FoxP3-expressing or non-expressing subsets of human CD4+ T cells
Gene expression profiles of subsets of CD4+ T cells according to their expression of FoxP3 and CD45RA were compared. Abstract: FoxP3 is a key transcription factor for the development and function of natural CD4+ regulatory T cells (Tregs). Here we show that human FoxP3+CD4+ T cells are composed of...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-15659 | biostudies-arrayexpress
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