Retinal microglia

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Metabolite Name

5-Carboxy-2-pentenoyl-CoA (1)
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A alpha C (1)
Fe-coproporphyrin III (1)
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Pelargonidin 3-O-3'',6''-O-dimalonylglucoside (1)
6-Hydroxytryprostatin B (1)
DTDP-6-deoxy-beta-L-talose (1)
Cis-4-Hydroxy-L-proline (1)
Tabernamine (1)
Profenofos (1)
Dimethenamid (1)
Omethoate (1)
Phenthoate (1)
Vincristine (1)
PI (40:6) (1)
PI (38:6).(16:0/22:6) (1)
PI (38:5)c (1)

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Study type

Transcription profiling by array (19)
RNA-seq of coding RNA (7)
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Lab affiliation

Associate Professor of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine (1)
Bascom Palmer Eye Institute University of Miami (1)
Cedars-Sinai, Neurosurgery - Pavilion, 127 S San Vicente Blvd #A6600, Los Angeles, CA, 90048 (1)
Department Functional Proteomics Medizinisches Proteom-Center Ruhr-University Bochum Building ProDi Gesundheitscampus 4 44780 Bochum Germany (1)
Department of Ophthalmology, LMU University Hospital, LMU Munich, Munich, Germany (1)
Laboratory of Neural Development and Regeneration, CIBIO Department - University of Trento Via Sommarive 9, 38123 Trento, ITALY Centre for Medical Sciences - CISMed University of Trento Via S. Maria Maddalena 1, 38122 Trento, Italy (1)
School of Optometry, The Hong Kong Polytechnic University, Hong Kong (1)
The Hong Kong Polytechnic University (1)

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Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis

Alzheimer’s disease (AD) is characterized by a prolonged asymptomatic phase before cognitive decline emerges, yet the mechanisms driving symptom onset remain unclear. Here, we hypothesized that the transition from asymptomatic to symptomatic disease is linked to dysfunction of brain–immune communica...

2026-06-01 | MTBLS14615 | MetaboLights

Microglia in ischemic brain injury

Microglia are resident CNS immune cells that are active sensors in healthy brain and versatile effectors under pathological conditions. Cerebral ischemia induces a robust neuroinflammatory response that includes marked changes in the gene expression and phenotypic profile of a variety of endogenous ...

ORGANISM(S): Mus musculus

2010-10-05 | E-GEOD-18602 | biostudies-arrayexpress

Defining the microglia transcriptome during disease progression in ALS transgenic mice

Purpose: We purified spinal cord microglia utilizing percoll gradients and magnetic beads, followed by transcriptome profiling (RNA-seq) to define microglia expression profiles against other neural, immune cell-types. We next observed how the microglial transcriptomes change during activation in the...

ORGANISM(S): Mus musculus

2013-07-15 | E-GEOD-43366 | biostudies-arrayexpress

APOE4 retinal microglia remain homeostatic in glaucoma.

PRJNA791674 | ENA

In-depth molecular profiling specifies human retinal microglia identity

PRJNA795163 | ENA

RNA-seq of STZ-treated mouse retinal microglia cells

PRJNA917303 | ENA

Mutant Huntingtin promotes neuronal death through cell autonomous microglial activation via myeloid lineage- determining factors

Huntington's Disease (HD) is a fatal neurodegenerative disorder caused by an extended polyglutamine repeat in the N-terminus of the huntingtin (Htt) protein. Reactive microglia and elevated cytokine levels are observed in the brains of HD patients, but the extent to which neuroinflammation results f...

ORGANISM(S): Mus musculus

2014-03-02 | E-GEOD-54443 | biostudies-arrayexpress

In order to evaluate the gene expression profile of retinal microglia cells in different age, we purified CD11b-positive microglia from the retinas of wild type C57BL/6 mice at 3, 12, 18, and 24 months age using cell sorting method with flow cytometry. Age-related genes from isolated retinal microg...

ORGANISM(S): Mus musculus

2012-12-01 | E-GEOD-38739 | biostudies-arrayexpress

Microglia suppress Ascl1-induced retinal regeneration in mice.

PRJNA678013 | ENA

Retinal microglia transition to a neurodegenerative MGnD phenotype in glaucoma.

PRJNA791672 | ENA