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ProteomicsDevelopment of next-generation retinoid pathway immunotherapeutics through targeting tumor ALDH1a3
Aldehyde dehydrogenase (ALDH1) activity has long been established as a pro-tumorigenic feature of many cancers, yet the identification of specific isoforms that are enriched in cancer, the mechanism of action of this isoform(s), and viable therapeutic strategies to target this pathway have long rema...
ORGANISM(S): Homo sapiens (Human) 
2025-08-26 | PXD052693 | Pride
Human cancer Aldh inhibitors Cancer immunotherapy Retinoid antagonist 
TranscriptomicsRetinoid X Receptor activation reverses the age-related deficiency in myelin debris phagocytosis and enhances remyelination
The efficiency of central nervous system (CNS) remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In this study we show that expression of genes i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66988 | biostudies-arrayexpress
TranscriptomicsEffects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos
Retinoid X receptor (RXR) plays an important role in the development of vertebrates, and the agonists of RXR are well-known to induce featured malformations in vertebrate embryos. However, there is no information about the teratogenicity of antagonists of RXR in vertebrate embryos. We exposed embryo...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2014-02-13 | E-GEOD-54929 | biostudies-arrayexpress
TranscriptomicsEffects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos
Retinoid X receptor (RXR) plays an important role in the development of vertebrates, and the agonists of RXR are well-known to induce featured malformations in vertebrate embryos. However, there is no information about the teratogenicity of antagonists of RXR in vertebrate embryos. We exposed embryo...
ORGANISM(S): Xenopus tropicalis 
2014-02-13 | GSE54929 | GEO
UnknownA Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice.
Not available
S-EPMC12422176 | biostudies-literature
UnknownPremature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co-Administration of a Retinoid Antagonist in Mice.
Not available
S-EPMC9661967 | biostudies-literature
UnknownDiscovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB.
Not available
S-EPMC4018080 | biostudies-literature
TranscriptomicsTranscription profiling of human freshly isolated PPARg and RARa ligand treated dendritic cells
Our data indicated that activation of the PPARg nuclear receptor induces a retinoid response in human dendritic cells. In order to assess the contribution of retinoid signaling to the PPARg response we decided to use a combination of pharmacological activators and inhibitors of these pathways. Cells...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-5679 | biostudies-arrayexpress
UnknownRetinoid X Receptor Antagonists.
Not available
S-EPMC6121510 | biostudies-literature
GenomicsXenopus tropicalis
Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos
PRJNA238052 | ENA
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