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TranscriptomicsSignaling to Transcription Networks in the Neuronal Retrograde Injury Response
Retrograde signaling from axon to soma activates intrinsic regeneration mechanisms in lesioned peripheral sensory neurons; however, the links between axonal injury signaling and the cell body response are not well understood. Here, we used phosphoproteomics and microarrays to implicate ~900 phosphop...
ORGANISM(S): Rattus norvegicus 
2010-12-29 | E-GEOD-26350 | biostudies-arrayexpress
MetabolomicsLipidomics study for investigating the role of the Unfolded Protein Response In Arabidopsis seed filling

The Unfolded Protein Response (UPR) is a retrograde, ER-to-nucleus, signalling pathway which is conserved across kingdoms. In plants, it contributes to development, reproduction, immunity and tolerance to abiotic stress. This lipidomic dataset was produced from Arabidopsis thaliana mature seeds. ...

2024-12-02 | MTBLS10597 | MetaboLights
TranscriptomicsCommunication between mitochondria and nucleus: defining a retrograde response in fission yeast
Retrograde response was widely studied in budding yeast but the main transcription factors that transmit it (RTG1,2 and 3) are not conserved in other organisms, thus it is interesting to study how communication between mitochondria and nucleus evolved in distantly related fission yeast, and which ar...
ORGANISM(S): Schizosaccharomyces pombe 
2016-11-01 | E-MTAB-4520 | biostudies-arrayexpress
TranscriptomicsRetrograde signalling during caused by heritable mitochondrial dysfunction is partly mediated by ANAC017 and improves plant performance.
Mitochondria are crucial for plant viability and are able to communicate information on their functional status to the cellular nucleus via retrograde signalling, thereby affecting gene expression. It is currently unclear if retrograde signalling in response to constitutive mitochondrial biogenesis ...
ORGANISM(S): Arabidopsis thaliana 
2016-07-28 | E-MTAB-4655 | biostudies-arrayexpress
TranscriptomicsArabidopsis transcription factor ANAC017 is a necessary and central control point for normal transcriptome changes in response to reactive oxygen signals, such as H2O2, and specific mitochondrial retrograde stress signals
Stresses that target mitochondrial function lead to altered transcriptional responses for 100-1000s of genes genome wide, and are signalled via retrograde communication pathways within the cell. rao2 mutants contain a mutation in the NAC family transcription factor ANAC017 and cannot induce stress r...
ORGANISM(S): Arabidopsis thaliana 
2013-01-30 | E-GEOD-41136 | biostudies-arrayexpress
GenomicsPeroxisomal retrograde signaling in C. elegans
Peroxisomal retrograde signaling in C. elegans
PRJNA657442 | ENA
TranscriptomicsCyclin-dependent protein kinase E;1 (CDKE;1) is an essential component for mitochondrial retrograde signalling in Arabidopsis thaliana
Stresses that target mitochondrial function lead to altered transcriptional responses for 100-1000s of genes genome wide, and are signalled via retrograde signalling pathways within the cell. rao1 mutants contain a mutation in a gene encoding a Cyclin-Dependant Kinase E;1 and cannot induce stress re...
ORGANISM(S): Arabidopsis thaliana 
2013-01-28 | E-GEOD-36011 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis thaliana seedlings with altered enzymes activity of the tetrapyrrole biosynthesis pathway
The CHLD and CHLM genes encode proteins involved in tetrapyrrole biosynthesis pathway. It was proposed that intermediates like magnesium protoporphyrin might play a role in retrograde plastid-to-nucleus signaling. In the present work we provide evidence that altered enzymes activity of the tetrapyrr...
ORGANISM(S): Arabidopsis thaliana 
2013-04-01 | E-GEOD-41884 | biostudies-arrayexpress
Proteomicslincomycin treatment wild type and gun1-101
Retrograde signals emanate from the DNA-containing cell organelles (plastids and mitochondria) and control the expression of a large number of nuclear genes in response to environmental and developmental cues. Previous studies on retrograde signaling mainly analyzed the regulation of nuclear gene ex...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-06-05 | PXD011759 | Pride
Arabidopsis Retrograde signaling 
ProteomicsAn impaired respiratory electron chain triggers retrograde response and de-ubiquitination of solute carrier amino acid transporters
Hundreds of genes have been associated with respiratory chain disease so far. Elimination of the respiratory electron chain by depleting the entire mitochondrial DNA (mtDNA, ��0 cells) has therefore one of the most severe impacts on the energy metabolism in eukaryotic cells. Here, we integrated prot...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD002270 | Pride
Proteome profiling Ρ0 cells Metabolome profiling Mass spectrometry Ubiquitination Retrograde response Oxphos deficiency 
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