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We use ChIP-seq targeting histone 3 lysine 4 mono-methylation (H3K4me1) to identify putative enhancer sites genome-wide, in the retrosplenial cortex of adult prairie vole males. ChIP samples were generated by targeting a known enhancer mark (H3K4me1) in chromatin extracted from the retrosplenial co...
ORGANISM(S): Microtus ochrogaster 
Samples were the retrosplenial cortex dissected from female Fischer F344 rats that were 3-, 12-, or 23 months old.
ORGANISM(S): Rattus norvegicus (Rat) 
2024-08-01 | PXD051203 | Pride

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
Transcriptomic landscape of the retrosplenial cortex of the mouse
Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease [Xenium]
Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease [GeoMx]
Here, we examined diversity in the cell-type composition of the mouse retrosplenial cortex using single-cell RNA-seq.
ORGANISM(S): Mus musculus 
2023-02-03 | GSE200027 | GEO
G72 transgenic (TG, transgenic mice carrying the G72/G30 locus) and wildtype (WT) mice with a CD1 background were used for transcriptome data acquisition. Importantly, three different brain regions, i.e., the retrosplenial cortex, the hippocampus and thalamus, of animals from both sexes were investi...
ORGANISM(S): Mus musculus 
Alzheimer’s disease is a debilitating neurodegenerative disorder with no cure and few treatment options. In early stages of Alzheimer’s disease, impaired metabolism and functional connectivity of the retrosplenial cortex strongly predict future cognitive impairments. Therefore, understanding Alzheim...
ORGANISM(S): Mus musculus 
2025-04-13 | GSE277793 | GEO
Alzheimer’s disease is a debilitating neurodegenerative disorder with no cure and few treatment options. In early stages of Alzheimer’s disease, impaired metabolism and functional connectivity of the retrosplenial cortex strongly predict future cognitive impairments. Therefore, understanding Alzheim...
ORGANISM(S): Mus musculus 
2025-04-13 | GSE277463 | GEO
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