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TranscriptomicsReverse transcriptase inhibitors in Aicardi-Goutières syndrome
Aicardi-Goutières syndrome (AGS) is a genetically heterogeneous encephalopathy whose pathology is linked to an abnormal type I interferon response induced by self-derived nucleic acids. Data indicate that endogenous retroelements represent one source of interferon-stimulatory self-nucleic acid. No e...
ORGANISM(S): Homo sapiens 
2018-12-12 | E-MTAB-7087 | biostudies-arrayexpress
GenomicsSequencing of Echinococcus multilocularis telomerase reverse transcriptase gene
Sequencing of Echinococcus multilocularis telomerase reverse transcriptase gene
PRJEB32610 | ENA
GenomicsReverse transcriptase inhibitors in Aicardi-Goutières syndrome
Reverse transcriptase inhibitors in Aicardi-Goutières syndrome
PRJEB27958 | ENA
ProteomicsReverse Transcriptase Inhibitors regulate LINE-1 expresion, modulate ORF1p protein interactions, and activate autophagy in cancer cells
Long Interspersed Element-1 (LINE-1; L1) is an autonomous retrotransposon whose expression is frequently dysregulated in cancer. L1 encodes two proteins, ORF1p and ORF2p, which are essential for retrotransposition. Reverse transcriptase inhibitors (RTIs), including nucleoside (NRTIs) and non-nucleos...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD082586 | Pride
Human  ip-ms  line-1  orf1p 
UnknownTy3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
Not available
S-EPMC6321743 | biostudies-literature
GenomicsEvolution of a Reverse Transcriptase to Map N1-Methyladenosine in Human mRNA
Evolution of a Reverse Transcriptase to Map N1-Methyladenosine in Human mRNA
PRJNA508500 | ENA
GenomicsDe novo gene synthesis by an antiviral reverse transcriptase [RNA-seq]
De novo gene synthesis by an antiviral reverse transcriptase [RNA-seq]
PRJNA1125609 | ENA
GenomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (ChIP-Seq)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-60223 | biostudies-arrayexpress
GenomicsDe novo gene synthesis by an antiviral reverse transcriptase [RIP-seq]
De novo gene synthesis by an antiviral reverse transcriptase [RIP-seq]
PRJNA1125610 | ENA
GenomicsDe novo gene synthesis by an antiviral reverse transcriptase [cDIP-seq]
De novo gene synthesis by an antiviral reverse transcriptase [cDIP-seq]
PRJNA1125611 | ENA
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