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MetabolomicsDEGS1-mTORC1-driven lipid metabolic reprogramming fuels rhabdomyosarcoma progression and unveils a therapeutic vulnerability
These findings establish a mechanistic link between sphingolipid metabolism, mTORC1-mediated regulation of lipophagy, and tumor aggressiveness, highlighting lipid droplet metabolism as a novel and tractable therapeutic target in RMS.
2026-10-02 | MTBLS15896 | MetaboLights
TranscriptomicsMouse Models of Alveolar/Embryonal Rhabdomyosarcoma & Spindle Cell Sarcomas
A series of conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma were generated and validated for relavence to corresponding human cancers. Conditional mouse models of embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma and spindle cell sarcoma...
ORGANISM(S): Mus musculus 
2011-02-17 | E-GEOD-22520 | biostudies-arrayexpress
TranscriptomicsA mouse model of rhabdomyosarcoma originating from the adipocyte lineage
Activation of Sonic Hedgehog signaling through expression of a constitutively active Smoothened allele under control of an aP2 adipocyte-restricted transgene in mice gives rise to aggressive skeletal muscle tumors that display the histologic and molecular characteristics of human embryonal rhabdomyo...
ORGANISM(S): Mus musculus 
2012-10-22 | E-GEOD-40359 | biostudies-arrayexpress
TranscriptomicsExpression profile of zebrafish embryonal rhabdomyosarcoma
Fluorescent-labeled zebrafish RAS-induced embryonal rhabdomyosarcoma (ERMS) were created to facilitate in vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in diverse cellular compartments. Using this strategy, we have identified a molecularly distinc...
ORGANISM(S): Danio rerio 
2012-12-01 | E-GEOD-32425 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pediatric alveolar (aRMS) and embryonal (eRMS) rhabdomyosarcoma, plus primary pediatric Ewings sarcoma (EWS)
Affymetrx U95Av2 GeneChip hybridizations, RNA extracted from primary human pediatric alveolar (aRMS) and embryonal (eRMS) rhabdomyosarcoma, plus primary pediatric Ewing's sarcoma (EWS)
ORGANISM(S): Homo sapiens 
2007-09-29 | E-GEOD-967 | biostudies-arrayexpress
ProteomicsPannexin 1 interactome in Rhabdomyosarcoma
We have recently reported the down-regulation of pannexin 1 (PANX1) levels in rhabdomyosarcoma (RMS) and that restoration of its expression inhibits the progression of embryonal (eRMS) and alveolar (aRMS) rhabdomyosarcoma in vitro and in vivo. While we have shown that this PANX1-mediated inhibition ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-30 | MSV000084867 | MassIVE
TranscriptomicsDynamic Pax3:Foxo1a expression of alveolar rhabdomyosarcoma
To define the specific function of Pax3:Foxo1a in G2/M stage, we compared whole mRNA expressions of mouse alveolar rhabdomyosarcoma tumor cells in G2/M stage (4N) with or without Pax3:Foko1a knockdown (si_YFP or si_control). The exerimental plan will include triplicate samples for sorted cells at G1...
ORGANISM(S): Mus musculus 
2014-03-19 | E-GEOD-41675 | biostudies-arrayexpress
TranscriptomicsExpression arrays of KRASG12D rhabdomyosarcoma models in zebrafish
Rhabdomyosarcoma is a pediatric malignancy thought to arise from the uncontrolled proliferation of myogenic cells. Here, we have generated models of rhabdomyosarcoma in the zebrafish by inducing oncogenic KRASG12D expression at different stages during muscle development. Several zebrafish promoter...
ORGANISM(S): Danio rerio 
2013-07-17 | E-GEOD-39731 | biostudies-arrayexpress
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
TranscriptomicsMouse alveolar rhabdomyosarcoma and wild-type skeletal muscle
The highly aggressive muscle cancer alveolar rhabdomyosarcoma (ARMS) is one of the most common soft tissue sarcoma of childhood, yet the outcome for unresectable and metastatic disease is dismal and unchanged for nearly 3 decades. To better understand the pathogenesis of this disease and to facilita...
ORGANISM(S): Mus musculus 
2009-08-27 | E-GEOD-15489 | biostudies-arrayexpress
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