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TranscriptomicsGlobal transcriptional profiling of Staphylococcus aureus treated with rhein
Staphylococcus aureus is one of the most important pathogens in humans and animals, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. Rhein, a natural plant product, has potential antimicrobial activity against Staphylococcus aureus. We emp...
ORGANISM(S): Staphylococcus aureus 
2010-06-10 | E-GEOD-8135 | biostudies-arrayexpress
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we ana...

2026-01-06 | MTBLS13603 | MetaboLights
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we analyze MRSA/CRE b...

2026-01-06 | MTBLS13611 | MetaboLights
ProteomicsAcetylomics on rhein treated NLRP3 activated J774A.1 macrophages
The aim of this project is to observe the effect of 5 μM rhein treatment on the acetylation level of NLRP3 activated macrophages. We primed J774A.1 cells with 100ng/mL LPS for 12 hours followed by 5μM rhein treatment for 30 minutes. Finally, the cells were stimulated with 4 mM ATP for 30 min to trig...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD044992 | Pride
Rhein Macrophage Nlrp3 inflammasome 
ProteomicsRhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis
Although fibrosis depicts a reparative mechanism, maladaptation of the heart due to excessive production of extracellular matrix accelerates cardiac dysfunction. The anthraquinone Rhein was examined for its anti-fibrotic potency to mitigate cardiac fibroblast-to-myofibroblast transition (FMT). Prima...
ORGANISM(S): Homo sapiens (Human) 
2020-03-23 | PXD016731 | Pride
Dia Spectronaut Hypoxia Fibrosis Lumos Cardiac remodeling Secretome Hdac inhibition 
GenomicsRhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency
Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency
PRJNA561082 | ENA
TranscriptomicsGlobal transcriptional profiling of Staphylococcus aureus treated with rhein
Staphylococcus aureus is one of the most important pathogens in humans and animals, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. Rhein, a natural plant product, has potential antimicrobial activity against Staphylococcus aureus. We emp...
ORGANISM(S): Staphylococcus aureus 
2007-06-15 | GSE8135 | GEO
TranscriptomicsRhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency
Rationale: Myocardial fibrosis manifests progressively in several forms of cardiomyopathies. Although fibrosis depicts a reparative mechanism, maladaptation of the heart due to excessive production of extracellular matrix accelerates cardiac dysfunction. Objective: The anthraquinone Rhein, a compoun...
ORGANISM(S): Homo sapiens 
2020-04-17 | GSE136039 | GEO
Genomics
Rhein against Phytophthora capsici
PRJNA1029350 | ENA
UnknownRhein antagonizes P2X7 receptor in rat peritoneal macrophages.
Not available
S-EPMC4564849 | biostudies-literature
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