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MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
GenomicsSouth Asia Rheumatic Heart Disease Genetics Network
Rheumatic heart disease (RHD) is a major cause of cardiovascular death and disability amongst young adults. Building on a sample collection established for and genotyped in several earlier successful candidate gene studies, this case-control study investigated host genetic susceptibility to RHD usin...
EGAS00001003565 | EGA
TranscriptomicsGenome-scale analysis of DNA methylation in rheumatic heart disease
The aim of the current study is to identify DNA methylation markers associated with rheumatic heart disease with secondary pulmonary arterial hypertension (RHD-PAH). Genome-wide DNA methylation study is performed among 6 RHD-PAH patients and 6 healthy controls using Illumina HumanMethylation 450K ar...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-84003 | biostudies-arrayexpress
GenomicsProfiling system-wide variations between Acute Rheumatic Fever and Rheumatic Heart Disease
Profiling system-wide variations between Acute Rheumatic Fever and Rheumatic Heart Disease
PRJNA861297 | ENA
GenomicsInvestigating genetic susceptibility to rheumatic heart disease in Oceania
This case-control study investigated susceptibility to rheumatic heart disease in over 3,000 individuals recruited across eight Oceanian countries. Cases were patients with rheumatic heart disease and controls were members of the general population. In addition to the Illumina HumanCore-24 BeadChip...
EGAS00001001881 | EGA
ProteomicsData independent acquisition mass spectrometry in severe Rheumatic Heart Disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases.
Rheumatic heart disease (RHD) remains a major source of morbidity and mortality in developing countries. A deeper insight into the pathogenetic mechanisms underlying RHD could provide opportunities for drug repurposing, guide recommendations for secondary penicillin prophylaxis, and/or inform develo...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030598 | Pride
Rheumatic heart disease Inflammation Protein signature Swath-mas 
TranscriptomicsValvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently
Background: Chronic atrial fibrillation (AF) is a complication associated with the dilated atria of patients with valvular heart disease and contributes to worsened pathology. Methods and Results: Using microarray technology, we examined microRNA (miR) expression profiles in right and left atrial ap...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress
UnknownAssociation between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania.
Not available
S-EPMC5437274 | biostudies-literature
GenomicsGenomic analysis of lncRNA and mRNA profile in circulating exosomes of patients with rheumatic heart disease
Genomic analysis of lncRNA and mRNA profile in circulating exosomes of patients with rheumatic heart disease
PRJNA533620 | ENA
GenomicsProfiling of long non-coding RNAs associated with atrial fibrillation in patients with rheumatic heart valvular disease
Profiling of long non-coding RNAs associated with atrial fibrillation in patients with rheumatic heart valvular disease
PRJNA428217 | ENA
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