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ProteomicsKinome profiling of Nf2-null murine Schwann cell line MS03 with defactinib and VS-4718
Patients with neurofibromatosis type 2-related schwannomatosis (NF2-SWN) develop hallmark tumors on their vestibular nerves, leading to hearing loss and numerous associated morbidities. Currently, there are no targeted therapeutic options for treating these tumors. In prior work, our group had ident...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-17 | PXD060730 | Pride
Focal adhesion kinase inhibitor Neurofibromatosis type 2-related schwannomatosis Multiplexed kinase inhibitor beads Kinase inhibitor 
ProteomicsPLK1 inhibition induces synthetic lethality in Fanconi anemia pathway-deficient acute myeloid leukemia
Overall survival of acute myeloid leukemia (AML) remains limited. Inhibitors of the master mitotic kinase PLK1 have emerged as promising therapeutics, demonstrating efficacy in an undefined subset of AML patients. However, the clinical success of PLK1 inhibitors remains hindered by a lack of predict...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-09 | MSV000096625 | MassIVE
UnknownTherapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload.
Not available
S-EPMC4631316 | biostudies-literature
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