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UnknownMMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.
Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots ...
S-EPMC5901377 | biostudies-literature
TranscriptomicsDNA methylation profiles of human bone samples
The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of human bone tissue and to relate it to chronological age. Toward this end, we used the epigenetic clock software described in Horvath S (2013) DNA methylation age of human tissues and cell types. Genom...
ORGANISM(S): Homo sapiens 
2015-06-03 | E-GEOD-64490 | biostudies-arrayexpress
UnknownGenetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women.

Background

Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study was to analyze the influence of common polymorphisms of the SHBG gene on ...
S-EPMC2615755 | biostudies-literature
UnknownHaplotypes of intron 4 of the estrogen receptor alpha gene and hip fractures: a replication study in Caucasians.

Background

Despite their great impact, few genetic association studies have used hip fractures as an endpoint. However, the association of two polymorphisms on intron 4 of estrogen receptor alpha (ESR1) with hip fractures was recently reported in a Chinese population. The aim of this study w...
S-EPMC2837017 | biostudies-literature
TranscriptomicsDNA methylation profiles of multiple human tissues
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-06-03 | E-GEOD-64511 | biostudies-arrayexpress
UnknownRole of DNA methylation in the regulation of the RANKL-OPG system in human bone.
Osteoblasts are specialized cells that form new bone and also indirectly influence bone resorption by producing factors that modulate osteoclast differentiation. Although the methylation of CpG islands plays an important role in the regulation of gene expression, there is still scanty information ab...
S-EPMC3337833 | biostudies-literature
UnknownAnalysis of Bone Histomorphometry in Rat and Guinea Pig Animal Models Subject to Hypoxia.
Hypoxia may be associated with alterations in bone remodeling, but the published results are contradictory. The aim of this study was to characterize the bone morphometry changes subject to hypoxia for a better understanding of the bone response to hypoxia and its possible clinical consequences on t...
S-EPMC9655516 | biostudies-literature
TranscriptomicsDNA methylation profiles of 30 tissues from a 112 year old woman
The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of these tissues. Toward this end, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10...
ORGANISM(S): Homo sapiens 
2015-06-03 | E-GEOD-64491 | biostudies-arrayexpress
UnknownEvaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model.

Background

Glaucoma is a blinding degenerative neuropathy in which the death of retinal ganglion cells (RGCs) causes progressive loss of visual field and eventually vision. Neuroinflammation appears to be a key event in the progression and spread of this disease. Thus, microglial immunomodul...
S-EPMC8892697 | biostudies-literature
UnknownEngineering a Pro-Osteogenic Secretome through the Transient Silencing of the Gene Encoding Secreted Frizzled Related Protein 1.
The evidence sustaining the regenerative properties of mesenchymal stem cells' (MSCs) secretome has prompted a paradigm change, where MSCs have shifted from being considered direct contributors to tissue regeneration toward being seen as cell factories for producing biotech medicines. We have previo...
S-EPMC10419110 | biostudies-literature
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