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ProteomicsProteomic Analysis of fly brain cytoplasmic RNP granules containing the lncRNA mimi
In neurons, mRNAs and associated RNA-binding proteins assemble into ribonucleoprotein (RNP) granules essential to regulate mRNA trafficking, local translation, and turnover. Dysregulation of RNA-protein condensation can disturb synaptic plasticity. We report that the novel lncRNA mimi is a constitut...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-12 | PXD034453 | Pride
Rnp granules  fly brain  neurons  lncrna mimi Fne  rbp9 Drosophila  relative ibaq  quantitative proteomics 
GenomicsDysregulated ribonucleoprotein granules impair mitochondrial activity in RBM20-dilated cardiomyopathy
Dysregulated ribonucleoprotein granules impair mitochondrial activity in RBM20-dilated cardiomyopathy
PRJNA1307415 | ENA
ProteomicsIntracellular Energy Controls Dynamics of Stress-induced Ribonucleoprotein Granules Implicated in ALS/FTD
Energy metabolism and membraneless organelles have been implicated in human diseases including neurodegeneration. How energy deficiency regulates ribonucleoprotein particles such as stress granules (SGs) is still unclear. Here we identified a unique type of granules formed under energy deficiency an...
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD035747 | Pride
Stress granule  energy metabolism  als/ftd  protein homeostasis 
TranscriptomicsChromatin immunoprecipitation of human HEK293 cells with flag-tagged IMP1 antibody
Isolation of IMP1 bound mRNAs. Flag-tagged IMP1 was expressed in HEK293 cells. Flag tagged IMP1 was immunoprecipitated and mRNAs isolated. As controls HEK293 cells that do not express Flag-tagged IMP1 was included.
ORGANISM(S): Homo sapiens 
2006-12-31 | E-MEXP-841 | biostudies-arrayexpress
UnknownEngineered Ribonucleoprotein Granules Inhibit Translation in Protocells.
Not available
S-EPMC6640848 | biostudies-literature
UnknownLocalization of oskar mRNA by agglomeration in ribonucleoprotein granules.
Not available
S-EPMC10484445 | biostudies-literature
UnknownPak1 kinase controls cell shape through ribonucleoprotein granules.
Not available
S-EPMC8318594 | biostudies-literature
ProteomicsThe Proteome and Transcriptome of Stress Granules and P-Bodies during Human T Lymphocytes Activation
Stress granules (SGs) and processing bodies (PBs) are membraneless cytoplasmic assemblies regulating mRNAs under environmental stress such as viral infections, neurological disorders, or cancer. Upon antigen stimulation, T lymphocytes mediate their immune functions under regulatory mechanisms involv...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD031639 | Pride
Human t lymphocytes Ribonucleoprotein granules Proteome 
UnknownIntracellular energy controls dynamics of stress-induced ribonucleoprotein granules.
Not available
S-EPMC9508253 | biostudies-literature
UnknownDysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.
Not available
S-EPMC9270981 | biostudies-literature
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