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TranscriptomicsRibosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
In higher eukaryotes, the large numbers of nuclear-encoded tRNA genes partially ensure the robustness of cytoplasmic protein translation. Here we discover that a loss-of-function in n-Tr20, a member of the nuclear-encoded tRNA Arg UCU family that is expressed specifically in the central nervous syst...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-56127 | biostudies-arrayexpress
TranscriptomicsIdentification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation
Identification of the coding elements in the genome is a fundamental step to understanding the building blocks of living systems. Short peptides (< 100 aa) have emerged as important regulators of development and physiology, but their identification has been limited by their size. We have leveraged t...
ORGANISM(S): Danio rerio 
2014-04-04 | E-GEOD-53693 | biostudies-arrayexpress
GenomicsSch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L (ChIP-Seq data)
TORC1 is a structurally and functionally conserved multiprotein complex that regulates many aspects of eukaryote growth including the synthesis and assembly of ribosomes. The protein kinase activity of this complex is responsive to environmental cues and is potently inhibited by the natural product ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-01 | E-GEOD-29124 | biostudies-arrayexpress
ProteomicsThe RNA helicase Dbp10 coordinates assembly factor association with PTC formation during ribosome biogenesis
During ribosome biogenesis a plethora of assembly factors and essential enzymes drive the unidirectional maturation of nascent pre-ribosomal subunits. The DEAD-box RNA helicase Dbp10 is suggested to restructure pre-ribosomal rRNA of the evolving peptidyl-transferase center (PTC) on nucleolar ribosom...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD046068 | Pride
Ribosome assembly. pre-60s Assembly factors S. cerevisiae 
TranscriptomicsRunx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Here we show that, counter-intuitively, Runx1 deficient hematopoietic stem and progenitor cells (HSPCs)...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67609 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type and rea1 mutant total and polysome-bound Transcriptomes
Analysis of gene expression level. The hypothesis tested in the present study was that rea1 mutant influence the translation level of translation and nucleosome assembly associated genes. Results provide important information of the gene translation level regulation of ribosome proteins, elongation...
ORGANISM(S): Zea mays 
2015-04-25 | E-GEOD-67083 | biostudies-arrayexpress
TranscriptomicsSnapshots of pre-rRNA structural flexibility reveal eukaryotic 40S assembly dynamics at nucleotide resolution
Ribosome assembly in eukaryotes involves the activity of hundreds of assembly factors that direct the hierarchical assembly of ribosomal proteins and numerous ribosomal RNA folding steps. However, detailed insights into the function of assembly factors and ribosomal RNA folding events are lacking. T...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-14 | E-GEOD-52878 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Arabidopsis thaliana wild-type and a putative chloroplast ribosome biogenesis mutant AtRsgA homozygous knockout
In this study, we have characterized a putative chloroplast ribosome assembly factor. To elucidate transcriptional responses caused by decreased chloroplast function, we have measured the transcriptome of wild-type and knock-down seedlings.
ORGANISM(S): Arabidopsis thaliana 
2018-08-16 | E-MTAB-6866 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type, dcgrA knock out and reconstituted wild type Aspergillus fumigatus to determine the contribution of CgrA to ribosome biogenesis
Study to determine the contribution of CgrA to ribosome biogenesis in Aspergillus fumigatus.
ORGANISM(S): Aspergillus fumigatus 
2008-01-03 | E-MEXP-1324 | biostudies-arrayexpress
ProteomicsUnexpected role of a truncated ribosome-associated chloroplast trigger factor homolog serving ribosome biogenesis in plants - Data set 2: Analysis of sedimented ribosomes
Molecular chaperones are essential throughout a protein's life and act already during protein synthesis. Bacteria and chloroplasts of plant cells share the ribosome-associated chaperone trigger factor (Tig1 in plastids), facilitating maturation of emerging nascent polypeptides. While typical trigger...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-03-11 | PXD052586 | Pride
Trigger factor Ribosome Arabidopsis Chloroplast 
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