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TranscriptomicsA protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2
The association between hyper-inflammatory states and numerous diseases is widely recognized, but our understanding of the molecular strategies that have evolved to prevent uncontrolled activation of inflammatory responses remains incomplete. Here, we report a critical, non-transcriptional role of G...
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-35197 | biostudies-arrayexpress
GenomicsChIP-seq of the multiple antibiotic resistance activator (MarA) protein and RNA polymerase sigma70 subunit of Enterotoxigenic Escherichia coli strain H10407
The experiment contains ChIP-seq data for Enterotoxigenic Escherichia coli strain H10407 transformed with plasmid pRGM9818. The strain was grown at 37 degrees in LB medium and crosslinked with 1 % (v/v) formaldehyde. After sonication, to break open cells and fragment DNA, immunoprecipitations were d...
ORGANISM(S): Escherichia coli 
2017-09-30 | E-MTAB-5521 | biostudies-arrayexpress
GenomicsChIP-seq of the multiple antibiotic resistance repressor (MarR) protein of Enterotoxigenic Escherichia coli strain H10407
The experiment contains ChIP-seq data for Enterotoxigenic Escherichia coli strain H10407 transformed with plasmids pAMNF (encoding an N-terminal MarR-3xFLAG fusion) or pAMNM (encoding an N-terminal MarR-8xmyc fusion). The cells was cultured at 37 degrees in LB medium and crosslinked with 1 % (v/v) f...
ORGANISM(S): Escherichia coli 
2017-12-01 | E-MTAB-5591 | biostudies-arrayexpress
TranscriptomicsGenome-wide activity of unliganded Estrogen Receptor alpha in breast cancer cells [RNA-Seq]
ERα is essential for the anti-proliferative response of breast cancer cells not only to estrogen antagonists, but also to estrogen withdrawal by means of aromatase inhibitors. We explored here one of the simplest explanation for this, consisting in the possibility that ERα may have a wide genomic fu...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-53532 | biostudies-arrayexpress
GenomicsGenome-wide activity of unliganded Estrogen Receptor alpha in breast cancer cells [ChIP-Seq]
Estrogen Receptor ? (ER?) has central role in hormone-dependent breast cancer and its ligand-induced functions have been extensively characterized. However, evidence exists that ER? has functions which are independent of ligands. In the present work, we investigated the binding of ER? to chromatin i...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-53531 | biostudies-arrayexpress
UnknownA multicenter retrospective study of charcot-marie-tooth disease type 4B (CMT4B) associated with mutations in myotubularin-related proteins (MTMRs).
Not available
S-EPMC6581441 | biostudies-literature
UnknownItalian survey about intraperitoneal drain use in distal pancreatectomy.
Not available
S-EPMC11876192 | biostudies-literature
TranscriptomicsGenomic and Transcriptomic Hallmarks of Poorly-Differentiated and Anaplastic Thyroid Cancers
BACKGROUND. Poorly-differentiated (PDTC) and anaplastic (ATC) thyroid cancers are rare and frequently lethal tumors, which so far have not been subjected to comprehensive genetic characterization. METHODS. We performed next generation sequencing of 341 cancer genes in 117 PDTCs and ATCs, and a tran...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-76039 | biostudies-arrayexpress
UnknownThe rapid spread of SARS-COV-2 Omicron variant in Italy reflected early through wastewater surveillance.
Not available
S-EPMC9074219 | biostudies-literature
UnknownWorldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2).
Not available
S-EPMC6195190 | biostudies-literature
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