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ProteomicsA Network Approach to Identify Biomarkers of Differential Chemotherapy Response Using Patient-Derived Xenograft Models of Triple Negative Breast Cancer
The authors develop a novel computational algorithm that identified two signatures of differential response to platinum-based and taxane chemotherapies in breast cancer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-15 | MSV000088233 | MassIVE
TranscriptomicsFunctional profiling in yeast with the benzene metabolites hydroquinone, catechol and 1,2,4-benzenetriol
Benzene is a ubiquitous environmental contaminant and is widely used in industry. Exposure to benzene causes a number of serious health problems, including blood disorders and leukemia. Benzene undergoes complex metabolism in humans, making mechanistic determination of benzene toxicity difficult. We...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-13 | E-GEOD-45116 | biostudies-arrayexpress
ProteomicsDirect evidence of milk consumption from ancient human dental calculus, St Helena
This study investigated the consumption of milk products in the archaeological record, utilizing human dental calculus as a reservoir of dietary proteins from archaeological samples from across Eurasia. Protein extraction and generation of tryptic peptides from dental calculus was performed using a ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079939 | MassIVE
ProteomicsDirect evidence of milk consumption from ancient human dental calculus, northern southwest Asia
This study investigated the consumption of milk products in the archaeological record, utilizing human dental calculus as a reservoir of dietary proteins from archaeological samples from across Eurasia. Protein extraction and generation of tryptic peptides from dental calculus was performed using a ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-18 | MSV000080064 | MassIVE
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation analysis and gene expression profiling identifies genes silenced in non-seminoma cell lines [methylation]
Germ cell tumours (GCTs) are a complex group of malignancies. They are unique in developing from a pluripotent progenitor cell. The initial lesion is believed to be the relatively benign precursor lesion (ICGNU), from which either highly chemosensitive seminomas or the more aggressive non-seminomas ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-65027 | biostudies-arrayexpress
ProteomicsMudPIT analyses of the proteins co-purified with components of the LSD1 (KDM1A) transcriptional repressor complex and the non-canonical BAF complex, immuno-precipitated from MKL-1 and WaGa MCC cell lines
Protein Complexes Purification: Immunoprecipitations were performed with antibodies to LSD1 (2139; Cell signaling technology), INSM1 Mouse (SC-271408, Santa Cruz Biotechnology), RCOR2 (23969-1-AP; Proteintech Group), BRD9 (61537; Active Motif Rabbit), and normal Rabbit IgG (2729; Cell signaling tech...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-01-25 | MSV000083364 | MassIVE
MetabolomicsGNPS - Effect of HDAC inhibition on metabolome of Aspergillus nidulans and discovery of many aspercryptins
Organic extracts of the wildtype mold species, Aspergillus nidulans, and a strain of A. nidulans where expression of the histone deacetylase (HDAC) RpdA was knocked-down. Biological triplicate of both strains are included.
ORGANISM(S): Aspergillus Nidulans Fgsc A4 (ncbitaxon:227321) 
2016-07-11 | MSV000079900 | GNPS
ProteomicsProteogenomic characterization of human colon and rectal cancer
Explore This Study at the NCI Proteomic Data Commons

Zhang, B., et al., Nature (2014) do...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-26 | MSV000084238 | MassIVE
ProteomicsDirect evidence of milk consumption from ancient human dental calculus, central Europe
This study investigated the consumption of milk products in the archaeological record, utilizing human dental calculus as a reservoir of dietary proteins from archaeological samples from across Eurasia. Protein extraction and generation of tryptic peptides from dental calculus was performed using a ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080765 | MassIVE
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