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TranscriptomicsMammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope
Repair of DNA Double Strand Breaks produced in transcriptionally active chromatin occurs through a mechanism, Transcription-Coupled DSB repair (TC-DSBR), that is yet poorly characterized. Here, using a screening approach scoring multiple outputs in human cells, we identified the PER complex, a key m...
ORGANISM(S): Homo sapiens 
2025-11-12 | E-MTAB-12712 | biostudies-arrayexpress
TranscriptomicsIdentification of Myc-regulated microRNAs in human P493 cells
We previously described the use of a spotted oligonucleotide array to identify the mir-17 cluster as a direct transcriptional target of Myc. In order to determine whether Myc regulates additional miRNAs, we produced custom microarrays with an expanded set of probes capable of assaying the expressio...
ORGANISM(S): Homo sapiens 
2007-12-05 | E-GEOD-9070 | biostudies-arrayexpress
TranscriptomicsIntegrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
The saprophytic mold Aspergillus fumigatus produces small (2-3 µm) airborne spores (conidia) that can reach the lung alveoli upon inhalation. There, they encounter the surfactant-rich environment of the alveolar epithelium and initiate swelling and germination. Primary alveolar macrophages are essen...
ORGANISM(S): Homo sapiens 
2026-10-02 | E-MTAB-17130 | biostudies-arrayexpress
TranscriptomicsRNA-seq of miRNA and piRNA of Exosomes and whole cell lysates from CHO-K1 Cell Cultures at different growth phases
In biopharmaceutical production, Chinese hamster ovary (CHO) cells derived from Cricetulus griseus remain the most commonly used host cell for recombinant protein production, especially antibodies. Over the last decade in-depth multi-omics characterization of these CHO cells provided data for extens...
ORGANISM(S): Cricetulus griseus 
2021-01-18 | E-MTAB-9894 | biostudies-arrayexpress
ProteomicsMudPIT analyses of the proteins co-purified with RAP01-HA, RAP21-HA, and negative controls from late asexual Plasmodium falciparum parasites
[NOTE: PF3D7_1470600 previously named RAP14 is now named RAP21]. HA-affinity purification - Purified late asexual parasites from parental and HA-tagged PF3D7_0105200 (RAP01-HA) and PF3D7_1470600 (RAP21-HA) lines were suspended in 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 5 mM EDTA, 1 % Triton X-100, 1 mM ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Plasmodium Falciparum 3d7 (ncbitaxon:36329) 
2020-12-24 | MSV000086636 | MassIVE
TranscriptomicsTranscription profiling by array of hippocampal regions CA1, CA3, and DG from aged, calorically restricted rats
Aging is associated with a decline in hippocampal mediated learning and memory, a process which can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (2...
ORGANISM(S): Rattus norvegicus 
2010-06-08 | E-GEOD-21681 | biostudies-arrayexpress
TranscriptomicsTranslation State Array Analysis of Thrombin Stimulated Human Endothelial Cells
Confluent human umbilical vein endothelial cells (HUVECs) were exposed to Thrombin (2 U/mL) for 2 hours. Ribosomal profiling via gradient centrifugation and fractionation was used to separate monosome, or under-translated, and polysome, or actively translated, mRNA species that were then used to pr...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4919 | biostudies-arrayexpress
UnknownBiallelic CRELD1 variants cause a multisystem syndrome, including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections.
Not available
S-EPMC10932913 | biostudies-literature
UnknownDrosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.
Not available
S-EPMC4426361 | biostudies-literature
UnknownAssociation of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus.
Not available
S-EPMC3103625 | biostudies-literature
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