Transcription profiling by array of hippocampal regions CA1, CA3, and DG from aged, calorically restricted rats

ABSTRACT: Aging is associated with a decline in hippocampal mediated learning and memory, a process which can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioural tests to assess their hippocampal function. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Thomas Foster 

PROVIDER: E-GEOD-21681 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress